Evidence map›Paper›PMID 25904139›Full record

ArticleRNA (New York, N.Y.)2015

Transcriptome sequencing uncovers novel long noncoding and small nucleolar RNAs dysregulated in head and neck squamous cell carcinoma.

Angela E Zou, Jonjei Ku, Thomas K Honda, Vicky Yu, Selena Z Kuo, Hao Zheng, Yinan Xuan, Maarouf A Saad, Andrew Hinton, Kevin T Brumund and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA (New York, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.

  1. Pooled it
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  7. Plasma miRNAs across the Alzheimer's disease continuum: Relationship to central biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
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  19. Cancer management and research · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Angela E ZouDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California, San Diego, La Jolla, California 92093, USA.
Jonjei KuDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California, San Diego, La Jolla, California 92093, USA.
Thomas K HondaDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California, San Diego, La Jolla, California 92093, USA.
Vicky YuDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California, San Diego, La Jolla, California 92093, USA.
Selena Z KuoDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California, San Diego, La Jolla, California 92093, USA.
Hao ZhengDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California, San Diego, La Jolla, California 92093, USA.
Yinan XuanDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California, San Diego, La Jolla, California 92093, USA.
Maarouf A SaadDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California, San Diego, La Jolla, California 92093, USA.
Andrew HintonDepartment of Pediatrics, University of California, San Diego, La Jolla, California 92093, USA.
Kevin T BrumundDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California, San Diego, La Jolla, California 92093, USA.
Jonathan H LinVeterans Administration Medical Center and Department of Pathology, University of California, San Diego, La Jolla, California 92161, USA.
Jessica Wang-RodriguezVeterans Administration Medical Center and Department of Pathology, University of California, San Diego, La Jolla, California 92161, USA.
Weg M OngkekoDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California, San Diego, La Jolla, California 92093, USA.
University of California San Diego · US

Funding

Non-coding RNAs in salivary gland tumorR21DE023242 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ONGKEKO, RUTHERFORD M · 2012 to 2013
$417k
Cellular and Molecular Mechanisms of Age-Related Retinal DegenerationI01BX002284 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI LIN, JONATHAN · 2014 to 2023
–
BLRD VA I01 BX002284NIDCR NIH HHS DE023242NIDCR NIH HHS R21 DE023242
6 · The paper itself

Abstract

Head and neck squamous cell carcinoma persists as one of the most common and deadly malignancies, with early detection and effective treatment still posing formidable challenges. To expand our currently sparse knowledge of the noncoding alterations involved in the disease and identify potential biomarkers and therapeutic targets, we globally profiled the dysregulation of small nucleolar and long noncoding RNAs in head and neck tumors. Using next-generation RNA-sequencing data from 40 pairs of tumor and matched normal tissues, we found 2808 long noncoding RNA (lncRNA) transcripts significantly differentially expressed by a fold change magnitude ≥2. Meanwhile, RNA-sequencing analysis of 31 tumor-normal pairs yielded 33 significantly dysregulated small nucleolar RNAs (snoRNA). In particular, we identified two dramatically down-regulated lncRNAs and one down-regulated snoRNA whose expression levels correlated significantly with overall patient survival, suggesting their functional significance and clinical relevance in head and neck cancer pathogenesis. We confirmed the dysregulation of these noncoding RNAs in head and neck cancer cell lines derived from different anatomic sites, and determined that ectopic expression of the two lncRNAs inhibited key EMT and stem cell genes and reduced cellular proliferation and migration. As a whole, noncoding RNAs are pervasively dysregulated in head and squamous cell carcinoma. The precise molecular roles of the three transcripts identified warrants further characterization, but our data suggest that they are likely to play substantial roles in head and neck cancer pathogenesis and are significantly associated with patient survival.

Indexed as

AdultAgedAged, 80 and overCarcinoma, Squamous CellCell Line, TumorCell MovementCell ProliferationEpithelial-Mesenchymal TransitionFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHead and Neck NeoplasmsHigh-Throughput Nucleotide SequencingHumansMaleMiddle AgedRNA, Long NoncodingRNA, Small NucleolarHNSCClong noncoding RNAsRNA-sequencingsmall nucleolar RNAs

Identifiers

PMID25904139
PMCPMC4436665
OpenAlexW2129456233

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.