ArticleJournal of gastroenterology2016
Gastric atrophy and xanthelasma are markers for predicting the development of early gastric cancer.
Article in Journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- The global prevalence of gastric cancer in Helicobacter pylori-infected individuals: a systematic review and meta-analysis.BMC infectious diseases · 2023Pooled it
- Incidence of Gastric Adenocarcinoma in Those With Gastric Atrophy: A Systematic Review.Cureus · 2024Review
- Endoscopic Grading and Sampling of Gastric Precancerous Lesions: A Comprehensive Literature Review.Current oncology (Toronto, Ont.) · 2024Review
- Investigation of risk factors for metachronous recurrence in patients with early gastric adenocarcinoma by miRNA-mRNA integral profiling.Scientific reports · 2023Article
- [Clinical Application of the Kyoto Classification of Gastritis].The Korean journal of helicobacter and upper gastrointestinal research · 2023Review
- Adenoma arising from xanthoma in the transverse colon: a case report.Gastroenterology report · 2023Article
- Gastric xanthelasma is a warning sign forFrontiers in medicine · 2023Article
- Gastric Xanthoma: A Rare Case Report.Iranian journal of pathology · 2023Article
- Kyoto classification of gastritis: Advances and future perspectives in endoscopic diagnosis of gastritis.World journal of gastroenterology · 2022Article
- Gastric Cancer Screening in Japan: A Narrative Review.Journal of clinical medicine · 2022Review
- Consistency between the endoscopic Kyoto classification and pathological updated Sydney system for gastritis: A cross-sectional study.Journal of gastroenterology and hepatology · 2022Article
- Gastric Xanthelasma, Microsatellite Instability and Methylation of Tumor Suppressor Genes in the Gastric Mucosa: Correlation and Comparison as a Predictive Marker for the Development of Synchronous/Metachronous Gastric Cancer.Journal of clinical medicine · 2021Article
- Gastric Xanthoma Is Related to the Rapid Growth of Gastric Cancer.Journal of clinical medicine · 2021Article
- Gastric xanthoma is correlated with early gastric cancer of previouslyJGH open : an open access journal of gastroenterology and hepatology · 2021Article
- Stratification of gastric cancer risk using a deep neural network.JGH open : an open access journal of gastroenterology and hepatology · 2020Article
- Risk for gastric cancer in patients with gastric atrophy: a systematic review and meta-analysis.Translational cancer research · 2020Article
- Endoscopic Kyoto classification ofWorld journal of gastroenterology · 2020Review
- Gastric Xanthoma Associated with Gastric Cancer Development: An Updated Review.Canadian journal of gastroenterology & hepatology · 2020Review
- Endoscopic appearance of esophageal xanthoma.Endoscopy international open · 2019Article
- Assessment of Endoscopic Gastric Atrophy according to the Kimura-Takemoto Classification and Its Potential Application in Daily Practice.Clinical endoscopy · 2019Review
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe significance of gastric xanthelasma in relation to gastric cancer still remains unclear. We investigated whether gastric xanthelasma would be a useful marker for predicting the development of early gastric cancer.
methodsA total of 1823 patients who underwent a medical health checkup were enrolled. We examined the relationship between gastric xanthelasma and various clinical features, and in an endoscopic follow-up study investigated whether the presence of gastric xanthelasma was predictive of the development of early gastric cancer.
resultsIn the initial endoscopic examination, gastric xanthelasma was detected in 107 (5.9 %) of the 1823 patients. The presence of gastric xanthelasma was significantly associated with age ≥65 years, male gender, open-type atrophy, and the presence of diabetes mellitus (DM) (p < 0.0001, p < 0.0001, p < 0.0001, and p < 0.0001, respectively). During the endoscopic follow-up period, early gastric cancer was found in 29 (1.6 %) of the 1823 patients. Gastric cancer occurred in 15 (14.0 %) of 107 patients with gastric xanthelasma, whereas it occurred in 14 (0.8 %) of 1716 patients without (p < 0.0001). Multivariate analysis revealed that open-type atrophy and gastric xanthelasma were independently related to the development of gastric cancer (odds ratio 7.19 [2.50-20.83]; p = 0.0003 and 5.85 [2.67-12.82]; p < 0.0001, respectively). The presence of gastric xanthelasma was significantly predictive of gastric cancer development even in the selected high-risk groups with open-type atrophy or DM (p < 0.0001 or p < 0.0001, respectively).
conclusionsGastric xanthelasma is a useful marker for predicting the development of gastric cancer.
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