Evidence map›Paper›PMID 25904077›Full record

ArticleInternational journal of legal medicine2015

Ventilated postmortem computed tomography in children: feasibility and initial experience.

Owen J Arthurs, Anna Guy, Liina Kiho, Neil J Sebire

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Article in International journal of legal medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

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14citing papers in PubMed, 3 pooled it
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1 · What the graph read from it

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3 · Its place in the literature

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14 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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5 · Who and what money

Authors and funding

4 authors.

Owen J ArthursDepartment of Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3JH, UK, owen.arthurs@gosh.nhs.uk.
Anna Guy
Liina Kiho
Neil J Sebire

Funding

Department of Health NIHR-CS-012-002
6 · The paper itself

Abstract

objectivesVentilated postmortem computed tomography (vPMCT) is associated with improved pulmonary imaging compared to standard PMCT in adults. We aimed to evaluate the feasibility of performing ventilated PMCT in children.

methodsPostmortem thoracic CT was performed before (PMCT) and after ventilation (vPMCT). We used a range of mouthpieces, including endotracheal tubes, bag and mask and laryngeal mask airway (LMA). Hounsfield units of the lungs at PMCT were measured for normal and abnormal lung areas, before and after ventilation. All patients underwent full conventional autopsy and histology.

resultsTwelve patients underwent ventilated PMCT, median age 52 days (range 3-304 days). Ventilated PMCT provided diagnostic lung images in all 12 cases, compared to only three unventilated PMCT examinations (p < 0.005). In all cases, ventilated PMCT improved the image quality of aerated lungs irrespective of the method used. Average lung Hounsfield units decreased significantly with ventilation from pre-vPMCT values (-134.1 ± 215.1 vs post-vPMCT -531.8 ± 190.1; p < 0.001). LMA with continuous positive pressure ventilation subjectively provided the best results.

conclusionVentilated PMCT significantly improves lung aeration in children and can aid recognition of areas of abnormality in paediatric lungs. Such advances will improve accuracy and uptake of imaging-assisted autopsies in children.

Indexed as

Positive-Pressure RespirationFeasibility StudiesFemaleForensic MedicineHumansInfantInfant, NewbornLungMaleMultidetector Computed TomographyPredictive Value of TestsResuscitationSensitivity and Specificity

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