ReviewEuropean journal of drug metabolism and pharmacokinetics2015
Biochanin a: understanding the complexities in the paradoxical drug-drug interaction potential.
Review in European journal of drug metabolism and pharmacokinetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Modified Biochanin A Release from Dual pH- and Thermo-Responsive Copolymer Hydrogels.Polymers · 2021Article
- Potential Herb-Drug Interactions in the Management of Age-Related Cognitive Dysfunction.Pharmaceutics · 2021Review
- Biochanin A alleviates gingival inflammation and alveolar bone loss in rats with experimental periodontitis.Experimental and therapeutic medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Use of dietary products is on the rise due to health benefits associated with the ingestion of flavonoids contained in them. Biochanin A (BioA) is the major constituent of red clover extract and has undergone investigations for health benefits and drug interaction potential. In many instances, BioA has exhibited a clear anomaly in the in vivo pharmacokinetics of co-administered drugs which were contrary to the in vitro studies. The focus of this review is to critically evaluate several mechanisms that may come into play for the interpretation of the in vivo pharmacokinetic data of drugs co-administered with BioA.
Indexed as
Identifiers
25903969What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.