ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2015
Signals from the brain induce variation in avian facial shape.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44 citing papers in PubMed, 62 citations in OpenAlex.
- Atlas of cell types and regulatory elements underlying human facial diversity.Nature genetics · 2026Article
- Navigating the window: structural bottlenecks in avian craniofacial integration revealed by the ontogenetic patterning of shape variance.bioRxiv : the preprint server for biology · 2026Article
- Cis-regulatory evolution shapes facial diversity in birds and mammals.Science advances · 2026Article
- Positional programs in early murine facial development and their role in human facial shape variability.Nature communications · 2025Article
- PBX1 and PBX3 transcription factors regulate SHH expression in the Frontonasal Ectodermal Zone through complementary mechanisms.PLoS genetics · 2025Article
- Sonic hedgehog and fibroblast growth factor 8 regulate the evolution of amniote facial proportions.Communications biology · 2025Article
- Sonic Hedgehog Determines Early Retinal Development and Adjusts Eyeball Architecture.International journal of molecular sciences · 2025Article
- Dynamic evolutionary interplay between ontogenetic skull patterning and whole-head integration.Nature ecology & evolution · 2024Article
- A Novel Perspective on Neuronal Control of Anatomical Patterning, Remodeling, and Maintenance.International journal of molecular sciences · 2023Review
- Evolutionary mechanisms modulating the mammalian skull development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Evo Devo of the Vertebrates Integument.Journal of developmental biology · 2023Review
- Covariation of brain and skull shapes as a model to understand the role of crosstalk in development and evolution.Evolution & development · 2023Article
- Editorial: Cellular Mechanisms During Normal and Abnormal Craniofacial Development.Frontiers in cell and developmental biology · 2022Article
- Novel neuroanatomical integration and scaling define avian brain shape evolution and development.eLife · 2021Article
- Creating Avian Forebrain Chimeras to assess Facial Development.Journal of visualized experiments : JoVE · 2021Article
- Increased facial asymmetry in focal epilepsies associated with unilateral lesions.Brain communications · 2021Article
- Article
- Comparative growth in the olfactory system of the developing chick with considerations for evolutionary studies.Journal of anatomy · 2020Article
- Aberrant cell segregation in the craniofacial primordium and the emergence of facial dysmorphology in craniofrontonasal syndrome.PLoS genetics · 2020Article
- Insights Into the Complexity of Craniofacial Development From a Cellular Perspective.Frontiers in cell and developmental biology · 2020Review
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundHow developmental mechanisms generate the phenotypic variation that is the raw material for evolution is largely unknown. Here, we explore whether variation in a conserved signaling axis between the brain and face contributes to differences in morphogenesis of the avian upper jaw. In amniotes, including both mice and avians, signals from the brain establish a signaling center in the ectoderm (the Frontonasal ectodermal zone or "FEZ") that directs outgrowth of the facial primordia.
resultsHere we show that the spatial organization of this signaling center differs among avians, and these correspond to Sonic hedgehog (Shh) expression in the basal forebrain and embryonic facial shape. In ducks this basal forebrain domain is present almost the entire width, while in chickens it is restricted to the midline. When the duck forebrain is unilaterally transplanted into stage matched chicken embryos the face on the treated side resembles that of the donor.
conclusionsCombined with previous findings, these results demonstrate that variation in a highly conserved developmental pathway has the potential to contribute to evolutionary differences in avian upper jaw morphology. Developmental Dynamics 244:1133-1143, 2015. © 2015 Wiley Periodicals, Inc.
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