ArticleEuropean radiology2015
Veins in plaques of multiple sclerosis patients - a longitudinal magnetic resonance imaging study at 7 Tesla.
Article in European radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Review
- Improved susceptibility weighted imaging at ultra-high field using bipolar multi-echo acquisition and optimized image processing: CLEAR-SWI.NeuroImage · 2021Article
- Developmental Venous Anomalies are More Common in Patients with Multiple Sclerosis and Clinically Isolated Syndrome : Coincidence or Relevant?Clinical neuroradiology · 2021Article
- Iron Rims in Patients With Multiple Sclerosis as Neurodegenerative Marker? A 7-Tesla Magnetic Resonance Study.Frontiers in neurology · 2021Article
- An Overview of Venous Abnormalities Related to the Development of Lesions in Multiple Sclerosis.Frontiers in neurology · 2021Review
- The Use of the Central Vein Sign in the Diagnosis of Multiple Sclerosis: A Systematic Review and Meta-analysis.Diagnostics (Basel, Switzerland) · 2020Review
- Ultra-high-field 7-T MRI in multiple sclerosis and other demyelinating diseases: from pathology to clinical practice.European radiology experimental · 2020Review
- Investigation of Deep-Learning-Driven Identification of Multiple Sclerosis Patients Based on Susceptibility-Weighted Images Using Relevance Analysis.Frontiers in neuroscience · 2020Article
- Iron related changes in MS lesions and their validity to characterize MS lesion types and dynamics with Ultra-high field magnetic resonance imaging.Brain pathology (Zurich, Switzerland) · 2018Review
- Interleaved susceptibility-weighted and FLAIR MRI for imaging lesion-penetrating veins in multiple sclerosis.Magnetic resonance in medicine · 2018Article
- Morphology-Specific Discrimination between MS White Matter Lesions and Benign White Matter Hyperintensities Using Ultra-High-Field MRI.AJNR. American journal of neuroradiology · 2018Article
- Hematocrit Measurement with R2* and Quantitative Susceptibility Mapping in Postmortem Brain.AJNR. American journal of neuroradiology · 2018Article
- Identification of Chronic Active Multiple Sclerosis Lesions on 3T MRI.AJNR. American journal of neuroradiology · 2018Article
- Magnetic Resonance Imaging in Multiple Sclerosis.Cold Spring Harbor perspectives in medicine · 2018Review
- Spatiotemporal evolution of venous narrowing in acute MS lesions.Neurology(R) neuroimmunology & neuroinflammation · 2018Article
- Key clinical benefits of neuroimaging at 7T.NeuroImage · 2018Review
- Association of Developmental Venous Anomalies with Demyelinating Lesions in Patients with Multiple Sclerosis.AJNR. American journal of neuroradiology · 2018Article
- Slow expansion of multiple sclerosis iron rim lesions: pathology and 7 T magnetic resonance imaging.Acta neuropathologica · 2017Article
- The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative.Nature reviews. Neurology · 2016Review
- Spring cleaning: time to rethink imaging research lines in MS?Journal of neurology · 2016Review
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo monitor the venous volumes in plaques of patients with multiple sclerosis (MS) compared to an age-matched control group over a period of 3.5 years.
methodsTen MS patients underwent an annual neurological examination and MRI. Susceptibility-weighted imaging (SWI) combined with fluid-attenuated inversion recovery (FLAIR) or FLAIR-like contrast at 7 Tesla (7 T) magnetic resonance imaging (MRI) was used for manual segmentation of veins in plaques, in the normal-appearing white matter (NAWM) and in location-matched white matter of 9 age-matched controls. Venous volume to tissue volume ratio was assessed for each time point in order to describe the dynamics of venous volumes in MS plaques over time.
resultsMS plaques, which were newly detected during the study period, showed significantly higher venous volumes compared to the preplaque area 1 year before plaque detection and the corresponding NAWM regions. Venous volumes in established MS plaques, which were present already in the first scans, were significantly higher compared to the NAWM and controls.
conclusionsOur data underpin a relation of veins and plaque development in MS and reflect increased apparent venous calibers due to increased venous diameters or increased oxygen consumption in early MS plaques. KEY POINTS: • Longitudinal 7 T Magnetic Resonance Imaging study of intralesional veins in MS patients. • Venous volumes are significantly increased in newly detected and established MS plaques. • Venous volumes in established MS plaques show a trend to decrease with time.
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