Evidence map›Paper›PMID 25903576›Full record

ArticleJournal of clinical microbiology2015

High-Level Pan-Azole-Resistant Aspergillosis.

Jakko van Ingen, Henrich A L van der Lee, Antonius J M M Rijs, Eveline Snelders, Willem J G Melchers, Paul E Verweij

Abstract readCase Reports
In one paragraph

Article in Journal of clinical microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Insights intoJournal of fungi (Basel, Switzerland) · 2024
    Article
  2. Article
  3. Article
  4. Article
  5. Antimicrobial agents and chemotherapy · 2019
    Article
  6. Article
  7. Article
  8. Emergence of Echinocandin Resistance Due to a Point Mutation in theAntimicrobial agents and chemotherapy · 2017
    Article
  9. Review
  10. Changes in In Vitro Susceptibility Patterns of Aspergillus to Triazoles and Correlation With Aspergillosis Outcome in a Tertiary Care Cancer Center, 1999-2015.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jakko van IngenDepartment of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands.
Henrich A L van der LeeDepartment of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands.
Antonius J M M RijsDepartment of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands.
Eveline SneldersDepartment of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands.
Willem J G MelchersDepartment of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands.
Paul E VerweijDepartment of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands paul.verweij@radboudumc.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-level pan-azole-resistant Aspergillus fumigatus was recovered from four patients with chronic lung disease. In one patient, the development of progressive resistance followed long-term azole therapy and switching between antifungal azoles. The high-level pan-azole-resistant phenotypes were not associated with a specific cyp51A gene mutation. New strategies that avoid the development of progressive azole resistance are needed.

Indexed as

AdultAgedAntifungal AgentsAspergillus fumigatusAzolesCytochrome P-450 Enzyme SystemFemaleFungal ProteinsHumansMaleMicrobial Sensitivity TestsMiddle AgedMutationPulmonary AspergillosisYoung AdultAntifungal AgentsAzolescytochrome P-450 CYP51A, AspergillusCytochrome P-450 Enzyme SystemFungal Proteins

Identifiers

PMID25903576
PMCPMC4473200

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.