Trial reportJournal of veterinary internal medicine
Effect of a probiotic on prevention of diarrhea and Clostridium difficile and Clostridium perfringens shedding in foals.
Trial report in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 61 citations in OpenAlex.
- A Comprehensive Review of the Equine Gut Microbiome in Health and Disease.Veterinary sciences · 2026Review
- Prevalence ofCanadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2026Article
- How "pro" are probiotics for wildlife species? Novel data, lack of evidence, and future directions.ISME communications · 2026Article
- An Overview of Donkey Neonatology.Animals : an open access journal from MDPI · 2025Review
- Dietary supplementation of new-born foals with free nucleotides positively affects neonatal diarrhoea management.Irish veterinary journal · 2025Article
- Supplementation of Foals with aAnimals : an open access journal from MDPI · 2024Article
- Current Understanding of Equine Gut Dysbiosis and Microbiota Manipulation Techniques: Comparison with Current Knowledge in Other Species.Animals : an open access journal from MDPI · 2024Review
- The Microbiota and Equine Asthma: An Integrative View of the Gut-Lung Axis.Animals : an open access journal from MDPI · 2024Review
- Treatment approaches to horses with acute diarrhea admitted to referral institutions: A multicenter retrospective study.PloS one · 2024Article
- Effect of Sugar Beet Pulp on the Composition and Predicted Function of Equine Fecal Microbiota.Biology · 2023Article
- Clostridioides difficile infection and One Health: an equine perspective.Environmental microbiology · 2022Review
- Gut Microbiota Manipulation in Foals-Naturopathic Diarrhea Management, or Unsubstantiated Folly?Pathogens (Basel, Switzerland) · 2021Review
- Changes in the Fecal Microbiota Associated with a Broad-Spectrum Antimicrobial Administration in Hospitalized Neonatal Foals with Probiotics Supplementation.Animals : an open access journal from MDPI · 2021Article
- Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2020Review
- Review
- Foal Diarrhea: Established and Postulated Causes, Prevention, Diagnostics, and Treatments.The Veterinary clinics of North America. Equine practice · 2018Review
- Diagnosis and Treatment of Undifferentiated and Infectious Acute Diarrhea in the Adult Horse.The Veterinary clinics of North America. Equine practice · 2018Review
- Clinical Trials in Veterinary Medicine: A New Era Brings New Challenges.Journal of veterinary internal medicine · 2017Article
- Comparison of the fecal bacterial microbiota of healthy and diarrheic foals at two and four weeks of life.BMC veterinary research · 2017Article
- In vitro and in vivo antagonistic activity of new probiotic culture against Clostridium difficile and Clostridium perfringens.BMC microbiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUp to 60% of foals develop diarrhea within 6 months after birth. Preventive measures are limited but potentially probiotics could be used.
objectiveTo evaluate the effect of a newly designed probiotic on the incidence of foal diarrhea in a randomized field trial. ANIMALS: Seventy-two healthy neonatal foals.
methodsRandomized, placebo-controlled field trial. Foals were administered a placebo or probiotic for 3 weeks and monitored for an additional week. A total of 3 fecal samples were taken from each foal at biweekly intervals. Statistical modeling was applied for comparison of incidence and duration of diarrhea and fecal shedding of Clostridium perfringens and Clostridium difficile between treatment and age groups.
resultsThe overall incidence of diarrhea was 41 of 72 (59%) and did not differ (P = 0.37) between treatment groups. Foals treated with probiotics were more likely to develop diarrhea requiring veterinary intervention (P = 0.007). Age had a significant effect on incidence of diarrhea (P < 0.001); foals 8-15 days old having the highest probability of developing diarrhea. Duration of diarrhea and soft feces were not significantly different between groups. The prevalence of C. perfringens shedding was 55% with no difference between treatment groups (P = 0.23). The prevalence of C. difficile shedding was 11%. CONCLUSION AND CLINICAL IMPORTANCE: There was no benefit of administering a 3-week course of probiotics, but potential adverse effects were noted. Whether the probiotics lacked a clinical effect, or the choice of strains or dose was inadequate, is unknown. Clostridial shedding was not influenced by probiotics despite in vitro activity of probiotics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.