ReviewHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2015
G-Protein β3-Subunit Gene C825T Polymorphism and Cardiovascular Risk: An Updated Review.
Review in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Single-Nucleotide Polymorphism in Genes Encoding G Protein SubunitsInternational journal of molecular sciences · 2023Article
- GNB3 c.825C>T (rs5443) Polymorphism and Risk of Acute Cardiovascular Events after Renal Allograft TransplantInternational journal of molecular sciences · 2022Article
- The Gβ1 and Gβ3 Subunits Differentially Regulate Rat Vascular Kv7 Channels.Frontiers in physiology · 2019Article
- Prediction of the Risk for Essential Hypertension among Carriers of C825T Genetic Polymorphism of G Protein β3 (GNB3) Gene.Biomarker insights · 2016Article
- Hypertension-associated C825T polymorphism impairs the function of Gβ3 to target GRK2 ubiquitination.Cell discovery · 2016Article
- Cardiovascular diseases-relatedJournal of inflammation (London, England) · 2016Article
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5 authors at 1 institution in 1 country.
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Abstract
Hypertension is a common disorder of multifactorial origin that constitutes a major risk factor for cardiovascular events such as stroke and myocardial infarction. The subunits of the heterotrimeric G proteins are attractive candidate gene products for susceptibility to hypertension, obesity and insulin resistance syndrome. A polymorphism (825C/T) in exon 10 of the GNB3 gene, encoding for the Gβ3 subunit, has been described. The 825T allele is associated with alternative splicing of the gene and formation of a truncated but functionally active β3 subunit. Many studies have investigated whether carriers of the 825T allele are at increased risk for hypertension, obesity, insulin-resistance and left ventricular hypertrophy with apparently conflicting results. The present review demonstrates that GNB3 825T allele is a useful genetic marker for better defining the risk profile of hypertensive patients, as it is associated with increased risk of stroke and myocardial infarction in longitudinal studies in Caucasians.
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