SynthesisNature communications2015
Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 9 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 9 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
107 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- The Genomics/Genetics of Primary Biliary Cholangitis: The Case for a Functional SNP rs10893900 in ETS1/FLI1 and Review of the Literature.Clinical reviews in allergy & immunology · 2025Pooled it
- GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets.Nature communications · 2025Pooled it
- Effects of tumor necrosis factor-alpha inhibitors on lipid profiles in patients with psoriasis: a systematic review and meta-analysis.Frontiers in immunology · 2024Pooled it
- Association of the rs1990760, rs3747517, and rs10930046 polymorphisms in theFrontiers in immunology · 2023Pooled it
- Psoriasis and cardiovascular disease risk in European and East Asian populations: evidence from meta-analysis and Mendelian randomization analysis.BMC medicine · 2022Pooled it
- Associations betweenBioMed research international · 2021Pooled it
- Exome-wide association study reveals novel psoriasis susceptibility locus at TNFSF15 and rare protective alleles in genes contributing to type I IFN signalling.Human molecular genetics · 2017Pooled it
- Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants.Nature communications · 2017Pooled it
- Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.American journal of human genetics · 2015Pooled it
- Genome-wide pQTL mapping in human skin identifies specific genetic regulators and mechanistic links to skin disorders.Nature communications · 2026Article
- Immunogenetics in psoriasis: towards personalised diagnosis and treatment strategies.Genes and immunity · 2026Review
- Observational
- Multi‑omics and their integration in psoriasis research (Review).Molecular medicine reports · 2026Review
- Factors influencing quality of life in patients with psoriasis: A large cross-sectional study.Chinese medical journal · 2026Article
- LZTR1 regulates epithelial MHC-I expression via NF-κB1 to modulate CD8Cell discovery · 2025Article
- Whole-genome sequencing reveals rare and structural variants contributing to psoriasis and identifies CERCAM as a risk gene.Cell genomics · 2025Article
- Disease-linked regulatory DNA variants and homeostatic transcription factors in epidermis.Nature communications · 2025Article
- Long Non-Coding RNAs in Psoriasis: A Comprehensive Review of Expression Profiles, Mechanistic Insights, Genetic Associations, and Their Clinical Implications.Non-coding RNA · 2025Review
- Identifying a Genetic Link Between Lung Function and Psoriasis.Annals of human genetics · 2025Article
- Exploring the Efficacy, Safety, and Clinical Implications of Deucravacitinib in East Asians with Psoriasis: A Narrative Review.Journal of clinical medicine · 2025Review
47 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
39 authors.
Xianyong Yin1] Institute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical University, Hefei, Anhui 230032, China [2] State Key Laboratory Incubation Base of Dermatology, Ministry of National Science and Technology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Lab of Dermatology (Anhui Medical University), Ministry of Education, Hefei, Anhui 230032, China [4] Collaborative Innovation Center for Complex and Severe Skin Diseases, Anhui Medical University, Hefei, Anhui 230032, China.
Hui Qi LowDepartment of Human Genetics, Genome Institute of Singapore, A*STAR, Singapore 138672, Singapore.
Ling WangDepartment of Human Genetics, Genome Institute of Singapore, A*STAR, Singapore 138672, Singapore.
Yonghong LiCelera, Alameda, California 94502, USA.
Eva EllinghausInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Schittenhelm Street 12, Kiel 24105, Germany.ORCID 0000000329143382
Jiali Han1] Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana 46202, USA [2] Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana 46202, USA [3] Department of Dermatology, School of Medicine, Indiana University, Indianapolis, Indiana 46202, USA.
Xavier Estivill1] Genetic Causes of Disease Group, Centre for Genomic Regulation (CRG), Barcelona, Catalonia, E-08003, Spain [2] Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Catalonia, E-08003, Spain [3] Hospital del Mar Medical Research Institute (IMIM), Barcelona, Catalonia, E-08003, Spain [4] CIBER in Epidemiology and Public Health (CIBERESP), Barcelona, Catalonia, E-08003, Spain.
Liangdan Sun1] Institute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical University, Hefei, Anhui 230032, China [2] State Key Laboratory Incubation Base of Dermatology, Ministry of National Science and Technology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Lab of Dermatology (Anhui Medical University), Ministry of Education, Hefei, Anhui 230032, China [4] Collaborative Innovation Center for Complex and Severe Skin Diseases, Anhui Medical University, Hefei, Anhui 230032, China.
Xianbo Zuo1] Institute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical University, Hefei, Anhui 230032, China [2] State Key Laboratory Incubation Base of Dermatology, Ministry of National Science and Technology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Lab of Dermatology (Anhui Medical University), Ministry of Education, Hefei, Anhui 230032, China [4] Collaborative Innovation Center for Complex and Severe Skin Diseases, Anhui Medical University, Hefei, Anhui 230032, China.
Changbing Shen1] Institute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical University, Hefei, Anhui 230032, China [2] State Key Laboratory Incubation Base of Dermatology, Ministry of National Science and Technology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Lab of Dermatology (Anhui Medical University), Ministry of Education, Hefei, Anhui 230032, China [4] Collaborative Innovation Center for Complex and Severe Skin Diseases, Anhui Medical University, Hefei, Anhui 230032, China.
Caihong Zhu1] Institute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical University, Hefei, Anhui 230032, China [2] State Key Laboratory Incubation Base of Dermatology, Ministry of National Science and Technology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Lab of Dermatology (Anhui Medical University), Ministry of Education, Hefei, Anhui 230032, China [4] Collaborative Innovation Center for Complex and Severe Skin Diseases, Anhui Medical University, Hefei, Anhui 230032, China.
Anping Zhang1] Institute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical University, Hefei, Anhui 230032, China [2] State Key Laboratory Incubation Base of Dermatology, Ministry of National Science and Technology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Lab of Dermatology (Anhui Medical University), Ministry of Education, Hefei, Anhui 230032, China [4] Collaborative Innovation Center for Complex and Severe Skin Diseases, Anhui Medical University, Hefei, Anhui 230032, China.
Fabio SanchezUnit of Dermatology and Venereology, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
Leonid PadyukovRheumatology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm 17177, Sweden.ORCID 0000000329505670
Joseph J CataneseCelera, Alameda, California 94502, USA.
Gerald G KruegerDepartment of Dermatology, University of Utah, Salt Lake, Utah 84132, USA.
Kristina Callis DuffinDepartment of Dermatology, University of Utah, Salt Lake, Utah 84132, USA.
Sören MuchaInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Schittenhelm Street 12, Kiel 24105, Germany.
Michael WeichenthalDepartment of Dermatology, University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany.
Stephan WeidingerDepartment of Dermatology, University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany.
Wolfgang LiebInstitute of Epidemiology and Biobank PopGen, Christian Albrechts University, Kiel, Germany.
Jia Nee FooDepartment of Human Genetics, Genome Institute of Singapore, A*STAR, Singapore 138672, Singapore.ORCID 0000000198992308
Yi LiDepartment of Human Genetics, Genome Institute of Singapore, A*STAR, Singapore 138672, Singapore.
Karseng SimDepartment of Human Genetics, Genome Institute of Singapore, A*STAR, Singapore 138672, Singapore.ORCID 0000000238227759
Herty LianyDepartment of Human Genetics, Genome Institute of Singapore, A*STAR, Singapore 138672, Singapore.
Ishak IrwanDepartment of Human Genetics, Genome Institute of Singapore, A*STAR, Singapore 138672, Singapore.
Yikying Teo1] Departments of Statistics and Applied Probability, National University of Singapore, Singapore 138672, Singapore [2] Department of Epidemiology and Public Health, National University of Singapore, Singapore 138672, Singapore.
Colin T S ThengNational Skin Centre, Singapore 308205, Singapore.
Rashmi GuptaDepartment of Dermatology, University of California San Francisco, San Francisco, California 94115, USA.
Anne BowcockNational Heart and Lung Institute, Imperial College, London SW3 6LY, UK.
Philip L De Jager1] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02138, USA [2] Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham &Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Abrar A Qureshi1] Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana 46202, USA [2] Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana 46202, USA [3] Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham &Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Paul I W de Bakker1] Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands [2] Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands.ORCID 0000000177357858
Mark Seielstad1] Department of Human Genetics, Genome Institute of Singapore, A*STAR, Singapore 138672, Singapore [2] Institute for Human Genetics, University of California San Francisco, San Francisco, California 94143, USA.ORCID 0000000157831401
Wilson LiaoDepartment of Dermatology, University of California San Francisco, San Francisco, California 94115, USA.
Mona StåhleUnit of Dermatology and Venereology, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
Andre FrankeInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Schittenhelm Street 12, Kiel 24105, Germany.
Xuejun Zhang1] Institute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical University, Hefei, Anhui 230032, China [2] State Key Laboratory Incubation Base of Dermatology, Ministry of National Science and Technology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Lab of Dermatology (Anhui Medical University), Ministry of Education, Hefei, Anhui 230032, China [4] Collaborative Innovation Center for Complex and Severe Skin Diseases, Anhui Medical University, Hefei, Anhui 230032, China.
Jianjun Liu1] State Key Laboratory Incubation Base of Dermatology, Ministry of National Science and Technology, Anhui Medical University, Hefei, Anhui 230032, China [2] Key Lab of Dermatology (Anhui Medical University), Ministry of Education, Hefei, Anhui 230032, China [3] Collaborative Innovation Center for Complex and Severe Skin Diseases, Anhui Medical University, Hefei, Anhui 230032, China [4] Department of Human Genetics, Genome Institute of Singapore, A*STAR, Singapore 138672, Singapore [5] Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, 138672, Singapore [6] School of Life Sciences, Anhui Medical University, Hefei, Anhui 230032, China.
Funding
Genome-Wide SNP Association in PsoriasisR01AR050266 · NIAMS · WASHINGTON UNIVERSITY · PI BOWCOCK, ANNE MARY · 2007 to 2016
$5.7MIdentification of Causal Variants in PsoriasisR01AR065174 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIAO, WILSON · 2013 to 2016
$1.8MGenetic Analysis of the TNF Pathway in PsoriasisK08AR057763 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIAO, WILSON · 2010 to 2014
$599kNIAMS NIH HHS K08 AR057763NIAMS NIH HHS K08AR057763NIAMS NIH HHS R01 AR050266NIAMS NIH HHS R01AR050266NIAMS NIH HHS R01 AR065174NIAMS NIH HHS R01AR065174
Abstract
Psoriasis is a common inflammatory skin disease with complex genetics and different degrees of prevalence across ethnic populations. Here we present the largest trans-ethnic genome-wide meta-analysis (GWMA) of psoriasis in 15,369 cases and 19,517 controls of Caucasian and Chinese ancestries. We identify four novel associations at LOC144817, COG6, RUNX1 and TP63, as well as three novel secondary associations within IFIH1 and IL12B. Fine-mapping analysis of MHC region demonstrates an important role for all three HLA class I genes and a complex and heterogeneous pattern of HLA associations between Caucasian and Chinese populations. Further, trans-ethnic comparison suggests population-specific effect or allelic heterogeneity for 11 loci. These population-specific effects contribute significantly to the ethnic diversity of psoriasis prevalence. This study not only provides novel biological insights into the involvement of immune and keratinocyte development mechanism, but also demonstrates a complex and heterogeneous genetic architecture of psoriasis susceptibility across ethnic populations.
Indexed as
Adaptor Proteins, Vesicular TransportAsian PeopleCase-Control StudiesCore Binding Factor Alpha 2 SubunitDEAD-box RNA HelicasesGenes, MHC Class IGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansInterferon-Induced Helicase, IFIH1Interleukin-12 Subunit p40PsoriasisTranscription FactorsTumor Suppressor ProteinsWhite PeopleAdaptor Proteins, Vesicular TransportCOG6 protein, humanCore Binding Factor Alpha 2 SubunitDEAD-box RNA HelicasesIFIH1 protein, humanIL12B protein, humanInterferon-Induced Helicase, IFIH1Interleukin-12 Subunit p40RUNX1 protein, humanTP63 protein, humanTranscription FactorsTumor Suppressor Proteins
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