SynthesisClinical research in cardiology : official journal of the German Cardiac Society2015
Prolonged dual antiplatelet therapy after drug-eluting stenting: meta-analysis of randomized trials.
Synthesis in Clinical research in cardiology : official journal of the German Cardiac Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Genotype-phenotype associations in dilated cardiomyopathy: meta-analysis on more than 8000 individuals.Clinical research in cardiology : official journal of the German Cardiac Society · 2017Pooled it
- Pooled it
- Shorter- versus Longer-duration Dual Antiplatelet Therapy in Patients with Diabetes Mellitus Undergoing Drug-eluting Stents Implantation: A Meta-analysis of Randomized Controlled Trials.Chinese medical journal · 2016Pooled it
- Pooled it
- Intra-procedural determination of viability by myocardial deformation imaging: a randomized prospective study in the cardiac catheter laboratory.Clinical research in cardiology : official journal of the German Cardiac Society · 2017Trial
- Dual antiplatelet therapy following percutaneous coronary intervention: protocol for a systematic review.BMJ open · 2019Article
- Lights and shadows of long-term dual antiplatelet therapy in "real life" clinical scenarios.Journal of thrombosis and thrombolysis · 2018Article
- Short versus long duration of dual antiplatelet therapy following drug-eluting stents: a meta-analysis of randomised trials.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2018Article
- Reversal of the platelet inhibitory effect of the P2YClinical research in cardiology : official journal of the German Cardiac Society · 2017Article
- Incidence and outcomes of early left ventricular thrombus following ST-elevation myocardial infarction treated with primary percutaneous coronary intervention.Clinical research in cardiology : official journal of the German Cardiac Society · 2017Article
- Adverse events with bioresorbable vascular scaffolds in routine percutaneous coronary interventions: "coup de théâtre" or unfinished play?Journal of thoracic disease · 2017Article
- Long-term outcomes in patients with acute coronary syndromes related to prolonging dual antiplatelet therapy more than 12 months after coronary stenting.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2017Article
- Duration of dual antiplatelet therapy after coronary stent insertion: Does the benefit of extended therapy outweigh the risk?Canadian family physician Medecin de famille canadien · 2016Review
- Article
- Stent thrombosis and restenosis: what have we learned and where are we going? The Andreas Grüntzig Lecture ESC 2014.European heart journal · 2015Review
- Long-Term Outcomes in Patients With Diabetes Mellitus Related to Prolonging Clopidogrel More Than 12 Months After Coronary Stenting.Journal of the American College of Cardiology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo investigate the benefits and the risks of a prolonged duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) with drug-eluting stent (DES) implantation. METHODS AND
resultsElectronic scientific databases were searched for randomized trials investigating the clinical impact of prolonged versus control DAPT duration in patients receiving a PCI with DES implantation. Primary outcomes were the incidence of stent thrombosis (ST), major bleeding and death. Secondary outcomes were the incidence of cardiac death, myocardial infarction (MI) and cerebrovascular event (CVE). The main analysis evaluated the primary outcomes by including events that occurred whereas therapies in the treatment groups actually differed. Events occurred at the longest follow-up available for each included trial contributed to risk estimates in a separate analysis. Odds ratio (95 % confidence interval) served as summary statistic. Ten trials totaling 32,194 participants were included in the meta-analysis. Median DAPT duration was 15 (12-24) versus 6 (6-12) months for the prolonged and control DAPT groups, respectively. After a median follow-up of 19.5 months, a prolonged versus control DAPT reduces the risk of ST [0.50 (0.29-0.85), P = 0.01] and MI [0.55 (0.45-0.67), P < 0.001], at the expense of higher risk of major bleeding [1.67 (1.31-2.13), P < 0.001] and death [1.25 (1.02-1.53), P = 0.03]. A prolonged versus control DAPT does not influence the risk of cardiac death [1.08 (0.82-1.44), P = 0.74] or CVE [0.84 (0.57-1.24), P = 0.39].
conclusionsProlonging the duration of dual antiplatelet therapy in patients undergoing PCI with DES implantation reduces the risk of stent thrombosis and myocardial infarction, but does result in an increased risk of major bleeding and death.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.