ReviewCNS spectrums2015
Advances from neuroimaging studies in eating disorders.
Review in CNS spectrums, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04225221 (Ovarian Hormones, Reward Response, and Binge Eating in Bulimia Nervosa), which is not on this map. Cited by 74 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Ovarian Hormones, Reward Response, and Binge Eating in Bulimia Nervosa: An Experimental Design
Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it, 142 citations in OpenAlex.
- A Systematic Review of Taste Differences Among People With Eating Disorders.Biological research for nursing · 2020Pooled it
- Trial
- Prefrontal and ventral striatal neural correlates of reversal learning in anorexia nervosa and bulimia nervosa.Cognitive, affective & behavioral neuroscience · 2026Article
- Sweet taste hedonic response in anorexia nervosa: connections with nutritional status and psychopathology.Eating and weight disorders : EWD · 2026Article
- Anorexia nervosa: 150 years of critical theory.Journal of eating disorders · 2026Review
- Disordered eating in early childhood: DRD2 and COMT gene polymorphisms and behavioral features in family trios.Eating and weight disorders : EWD · 2026Article
- Genetic risk and transdiagnostic traits in anorexia nervosa, obsessive-compulsive disorder, and schizophrenia.Psychological medicine · 2025Article
- Cardiometabolic health and physical robustness map onto distinct patterns of brain structure and neurotransmitter systems.PLoS biology · 2025Article
- Moderate to Vigorous Physical Activity as a Cause of Dietary Restriction in Eating Disorders.The International journal of eating disorders · 2025Review
- Restrained Eating Features and Brain Morphology: A Pediatric Population-Based Study.The International journal of eating disorders · 2025Article
- Interoceptive Dysfunction in Psychiatric Disorders and Non-invasive Neuromodulation for Improving Interoception.Neuroscience bulletin · 2025Review
- Mapping the Mind: Gray Matter Signatures of Personality Pathology in Female Adolescent Anorexia Nervosa Persist Through Treatment.Journal of clinical medicine · 2025Article
- Development of a pharmacodynamic biomarker of opioid antagonism in adolescents with eating disorders: Study protocol for the naltrexone neuroimaging randomized controlled trial (NN-RCT).Contemporary clinical trials · 2025Article
- Article
- Brain serotonin, oxytocin, and their interaction: Relevance for eating disorders.Journal of psychopharmacology (Oxford, England) · 2025Review
- Binge-type eating disorders and ultra-processed food addiction: phenomenology, pathophysiology and treatment implications.Frontiers in psychiatry · 2025Article
- Relationships of eating behaviors with psychopathology, brain maturation and genetic risk for obesity in an adolescent cohort study.Nature. Mental health · 2025Article
- Exploring the neurobiological correlates of psilocybin-assisted psychotherapy in eating disorders: a review of potential methodologies and implications for the psychedelic study design.Journal of eating disorders · 2024Review
- Neuroimaging studies of resting-state functional magnetic resonance imaging in eating disorders.BMC medical imaging · 2024Review
- Why Don't You Just Eat? Neuroscience and the Enigma of Eating Disorders.Focus (American Psychiatric Publishing) · 2024Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Over the past decade, brain imaging has helped to better define eating disorder-related brain circuitry. Brain research on gray matter (GM) and white matter (WM) volumes had been inconsistent, possibly due to the effects of acute starvation, exercise, medication, and comorbidity, but newer studies have controlled for such effects. Those studies suggest larger left medial orbitofrontal gyrus rectus volume in ill adult and adolescent anorexia nervosa after recovery from anorexia nervosa, and in adult bulimia nervosa. The orbitofrontal cortex is important in terminating food intake, and altered function could contribute to self-starvation. The right insula, which processes taste but also interoception, was enlarged in ill adult and adolescent anorexia nervosa, as well as adults recovered from the illness. The fixed perception of being fat in anorexia nervosa could be related to altered insula function. A few studies investigated WM integrity, with the most consistent finding of reduced fornix integrity in anorexia and bulimia nervosa-a limbic pathway that is important in emotion but also food intake regulation. Functional brain imaging using basic sweet taste stimuli in eating disorders during the ill state or after recovery implicated repeatedly reward pathways, including insula and striatum. Brain imaging that targeted dopamine-related brain activity using taste-reward conditioning tasks suggested that this circuitry is hypersensitive in anorexia nervosa, but hyporesponsive in bulimia nervosa and obesity. Those results are in line with basic research and suggest adaptive reward system changes in the human brain in response to extremes of food intake-changes that could interfere with normalization of eating behavior.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.