ArticleHypertension research : official journal of the Japanese Society of Hypertension2015
Exercise intensity-dependent reverse and adverse remodeling of voltage-gated Ca(2+) channels in mesenteric arteries from spontaneously hypertensive rats.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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17 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Cardiovascular effects of exercise training in spontaneously hypertensive rats: A systematic review and meta-analysis.Physiological reports · 2026Pooled it
- CaThe Journal of physiology · 2026Article
- Aerobic Exercise Prevents High-Fat-Diet-Induced Adipose Tissue Dysfunction in Male Mice.Nutrients · 2024Article
- Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes.Communications biology · 2022Article
- Activation of TRPV4 by lactate as a critical mediator of renal fibrosis in spontaneously hypertensive rats after moderate- and high-intensity exercise.Frontiers in physiology · 2022Article
- Aortic Stiffness in L-NAME Treated C57Bl/6 Mice Displays a Shift From Early Endothelial Dysfunction to Late-Term Vascular Smooth Muscle Cell Dysfunction.Frontiers in physiology · 2022Article
- Effects of different intensities of continuous training on vascular inflammation and oxidative stress in spontaneously hypertensive rats.Journal of cellular and molecular medicine · 2021Article
- Sex-Specific Impacts of Exercise on Cardiovascular Remodeling.Journal of clinical medicine · 2021Review
- Increased CaScientific reports · 2020Article
- Aerobic exercise enhanced endothelium-dependent vasorelaxation in mesenteric arteries in spontaneously hypertensive rats: the role of melatonin.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- Physical Exercise and Regulation of Intracellular Calcium in Cardiomyocytes of Hypertensive Rats.Arquivos brasileiros de cardiologia · 2018Article
- BKHypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- From apelin to exercise: emerging therapies for management of hypertension in pregnancy.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Review
- Epigenetic regulation of L-type voltage-gated CaHypertension research : official journal of the Japanese Society of Hypertension · 2017Article
- Exercise may be detrimental in hypertension: too much of a good thing!Hypertension research : official journal of the Japanese Society of Hypertension · 2015Article
- Microvascular Function and Exercise Training: Functional Implication of Nitric Oxide Signaling and Ion Channels.Pulse (Basel, Switzerland)Review
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6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Exercise can be regarded as a drug for treating hypertension, and the 'dosage' (intensity/volume) is therefore of great importance. L-type voltage-gated Ca(2+) (Cav1.2) channels on the plasma membrane of vascular smooth muscle cells have a pivotal role in modulating the vascular tone, and the upregulation of Cav1.2 channels is a hallmark feature of hypertension. The present study investigated the beneficial and adverse effects of exercise at different intensities on the remodeling of the Cav1.2 channel in mesenteric arteries (MAs) of spontaneously hypertensive rats (SHRs). Moderate- (SHR-M, 18-20 m min(-1)) and high-intensity (SHR-H, 26-28 m min(-1)) aerobic exercise training groups were created for SHRs and lasted for 8 weeks (1 h per day, 5 d per week). Age-matched sedentary SHRs and normotensive Wistar-Kyoto rats (WKY) were used as controls. The mesenteric arterial mechanical and functional properties were evaluated. Moderate-intensity exercise training induced a lower systolic blood pressure and heart rate in these rats compared with sedentary SHRs. BayK 8644 and nifedipine induced vasoconstriction and dose-dependent vasorelaxation, respectively, in the mesenteric arterial rings. Moderate-intensity exercise significantly suppressed the increase in BayK 8644-induced vasoconstriction, tissue sensitivity to nifedipine, Cav1.2 channel current density and Cav1.2 α1C-subunit protein expression in MAs from SHRs. However, high-intensity exercise training aggravated all of these hypertension-associated functional and molecular alterations of Cav1.2 channels. These results indicate that moderate-intensity aerobic training may act as a drug and effectively reverse the remodeling of Cav1.2 channels in hypertension to restore the vascular function in MAs, but that high-intensity exercise exaggerates the adverse remodeling of Cav1.2 channels and worsens the vascular function.
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