Evidence map›Paper›PMID 25902865›Full record

ArticleThe Analyst2015

In vivo histamine voltammetry in the mouse premammillary nucleus.

Srimal Samaranayake, Aya Abdalla, Rhiannon Robke, Kevin M Wood, Anisa Zeqja, Parastoo Hashemi

Open access · greenAbstract read
In one paragraph

Article in The Analyst, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 62 citations in OpenAlex.

  1. Review
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  13. Review
  14. Inflammation-Induced Histamine Impairs the Capacity of Escitalopram to Increase Hippocampal Extracellular Serotonin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. New optical methods for detecting monoamine neuromodulators.Current opinion in biomedical engineering · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Srimal SamaranayakeDepartment of Chemistry, Wayne State University, Detroit, USA. phashemi@chem.wayne.edu.
Aya Abdalla
Rhiannon Robke
Kevin M Wood
Anisa Zeqja
Parastoo Hashemi
Wayne State University · US

Funding

Voltammetric determination of neuronal serotonin and histamine co-regulationR21MH109959 · NIMH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI HASHEMI, PARASTOO · 2016 to 2017
$424k
NIMH NIH HHS R21 MH109959
6 · The paper itself

Abstract

Histamine plays a major role in the mediation of allergic reactions such as peripheral inflammation. This classical monoamine is also a neurotransmitter involved in the central nervous system but its role in this context is poorly understood. Studying histamine neurotransmission is important due to its implications in many neurological disorders. The sensitivity, selectivity and high temporal resolution of fast scan cyclic voltammetry (FSCV) offer many advantages for studying electroactive neurotransmitters. Histamine has previously been studied with FSCV; however, the lack of a robust Faradaic electrochemical signal makes it difficult to selectively identify histamine in complex media, as found in vivo. In this work, we optimize an electrochemical waveform that provides a stimulation-locked and unique electrochemical signal towards histamine. We describe in vitro waveform optimization and a novel in vivo physiological model for stimulating histamine release in the mouse premammillary nucleus via stimulation of the medial forebrain bundle. We demonstrate that a robust signal can be used to effectively identify histamine and characterize its in vivo kinetics.

Indexed as

Histamine ReleaseAdsorptionAnimalsCarbonCarbon FiberElectric ConductivityElectric StimulationElectrochemistryHistamineHypothalamus, PosteriorMaleMedial Forebrain BundleMiceMicroelectrodesCarbonCarbon FiberHistamine

Identifiers

PMID25902865
PMCPMC7279508
OpenAlexW2076176147

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.