ArticleBMC complementary and alternative medicine2015
Alkanna tinctoria leaves extracts: a prospective remedy against multidrug resistant human pathogenic bacteria.
Article in BMC complementary and alternative medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Integrated HPLC-ESI-QTOF-MS based characterization and biological evaluation of Alkanna orientalis and Alkanna verecunda roots.Scientific reports · 2026Article
- Ratanjot (Foods (Basel, Switzerland) · 2024Article
- Co-Delivery ofPharmaceutics · 2024Article
- Embryo and Fetal Toxic Effects of the Hydroethanol Extract ofJournal of toxicology · 2024Article
- Exploring pharmaphylogeny from multiple perspectives: a case study on Lithospermeae.Scientific reports · 2023Article
- Plant-Derived Products with Therapeutic Potential against Gastrointestinal Bacteria.Pathogens (Basel, Switzerland) · 2023Review
- Article
- Metabolic Profiles, Genetic Diversity, and Genome Size of Bulgarian Population ofPlants (Basel, Switzerland) · 2022Article
- Secondary plant metabolites as potent drug candidates against antimicrobial-resistant pathogens.SN applied sciences · 2022Review
- Review on the Antibacterial Mechanism of Plant-Derived Compounds against Multidrug-Resistant Bacteria (MDR).Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Genetic diversity, reproductive capacity and alkaloids content in three endemic Alkanna species.PloS one · 2020Article
- Glycyrrhiza glabra HPLC fractions: identification of Aldehydo Isoophiopogonone and Liquirtigenin having activity against multidrug resistant bacteria.BMC complementary and alternative medicine · 2018Article
- Review
- Punica granatum peel extracts: HPLC fractionation and LC MS analysis to quest compounds having activity against multidrug resistant bacteria.BMC complementary and alternative medicine · 2017Article
- EthnomedicinalJundishapur journal of microbiology · 2016Article
- Antimicrobial effects of Citrus sinensis peel extracts against dental caries bacteria: An in vitro study.Journal of clinical and experimental dentistry · 2016Review
- Article
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9 authors.
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Abstract
backgroundPlants are rich source of chemical compounds that are used to accomplish biological activity. Indigenously crude extracts of plants are widely used as herbal medicine for the treatment of infections by people of different ethnic groups. The present investigation was carried out to evaluate the biological potential of Alkanna tinctoria leaves extract from district Charsadda, Pakistan against multidrug resistant human pathogenic bacteria including Acinetobacter baumannii, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus.
methodsAnti-multi-drug resistant bacterial activity of aqueous, chloroform, ethanol and hexane extracts of Alkanna tinctoria leaves were evaluated by well diffusion method. Minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of different extracts were determined. Moreover qualitative phytochemicals screening of the studied extracts was performed.
resultsAll four selected bacteria including A. baumannii, E. coli, P. aeruginosa and S. aureus were categorized as multi-drug resistant (MDR) as they were found to be resistant to 13, 10, 19 and 22 antibiotics belonging to different groups respectively. All the four extract showed potential activity against S. aureus as compare to positive control antibiotic (Imipenem). Similarly among the four extracts of Alkanna tinctoria leaves, aqueous extract showed best activity against A. baumannii (10±03 mm), P. aeruginosa (12±0.5 mm), and S. aureus (14±0.5 mm) as compare to Imipenem. The MICs and MBCs results also showed quantitative concentration of plant extracts to inhibit or kill MDR bacteria. When phytochemicals analysis was performed it was observed that aqueous and ethanol extracts showed phytochemicals with large number as well as volume, especially Alkaloides, Flavonoides and Charbohydrates.
conclusionThe undertaken study demonstrated that all the four extracts of Alkanna tinctoria leaves exhibited considerable antibacterial activity against MDR isolates. Finding from the current study will be helpful for further elucidation of lead molecules from Alkanna tinctoria leaves for future therapeutic use against MDR pathogens.
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