ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2015
Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- An updated analysis on the association ofThe Journal of international medical research · 2022Pooled it
- A cell-type deconvolution meta-analysis of whole blood EWAS reveals lineage-specific smoking-associated DNA methylation changes.Nature communications · 2020Pooled it
- Genetic insights into 5-LOX-activating protein: a narrative review of disease associations.Human genomics · 2025Review
- Robust pleiotropy-decomposed polygenic scores identify distinct contributions to elevated coronary artery disease polygenic risk.PLoS computational biology · 2025Article
- Genetic associations and serum paraoxonase levels with atherosclerosis in western Iranian patients.Molecular biology reports · 2020Article
- Mediating effects of lipids on the association between smoking and coronary artery disease risk among Chinese.Lipids in health and disease · 2020Article
- Association of common gene-smoking interactions with elevated plasma apolipoprotein B concentration.Lipids in health and disease · 2020Article
- Interaction between COX-1 and COX-2 increases susceptibility to ischemic stroke in a Chinese population.BMC neurology · 2019Article
- Contributions of Interactions Between Lifestyle and Genetics on Coronary Artery Disease Risk.Current cardiology reports · 2019Review
- Article
- The arachidonic acid metabolism protein-protein interaction network and its expression pattern in esophageal diseases.American journal of translational research · 2018Article
- Trend in young coronary artery disease in China from 2010 to 2014: a retrospective study of young patients ≤ 45.BMC cardiovascular disorders · 2017Article
- Article
- Rs5498 polymorphism may be a risk factor for coronary heart disease in Chinese population: evidence from a meta-analysis involving 5537 subjects.International journal of clinical and experimental medicine · 2015Article
- A tagging ALOX5AP polymorphism and risk of ischemic stroke in a northeastern Chinese Han population.International journal of clinical and experimental medicine · 2015Article
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Authors and funding
18 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of inflammation in coronary artery disease (CAD) pathogenesis is well recognized. Moreover, smoking inhalation increases the activity of inflammatory mediators through an increase in leukotriene synthesis essential in atherosclerosis pathogenesis.
aimThe aim of this study is to investigate the effect of "selected" genetic variants within the leukotriene (LT) pathway and other variants on the development of CAD.
methodsCAD was detected by cardiac catheterization. Logistic regression was performed to investigate the association of smoking and selected susceptibility variants in the LT pathway including ALOX5AP, LTA4H, LTC4S, PON1, and LTA as well as CYP1A1 on CAD risk while controlling for age, gender, BMI, family history, diabetes, hyperlipidemia, and hypertension.
resultsrs4769874 (ALOX5AP), rs854560 (PON1), and rs4646903 (CYP1A1 MspI polymorphism) are significantly associated with an increased risk of CAD with respective odds ratios of 1.53703, 1.67710, and 1.35520; the genetic variant rs9579646 (ALOX5AP) is significantly associated with a decreased risk of CAD (OR 0.76163). Moreover, a significant smoking-gene interaction is determined with CYP1A1 MspI polymorphism rs4646903 and is associated with a decreased risk of CAD in current smokers (OR 0.52137).
conclusionThis study provides further evidence that genetic variation of the LT pathway, PON1, and CYP1A1 can modulate the atherogenic processes and eventually increase the risk of CAD in our study population. Moreover, it also shows the effect of smoking-gene interaction on CAD risk, where the CYP1A1 MspI polymorphism revealed a decreased risk in current smokers.
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