Evidence map›Paper›PMID 25902748›Full record

ArticleDigestive diseases and sciences2015

Characterization of Gastric Cardia Tumors: Differences in Helicobacter pylori Strains and Genetic Polymorphisms.

Débora Menezes da Costa, Eliane Dos Santos Pereira, Isabelle Joyce de Lima Silva-Fernandes, Márcia Valéria Pitombeira Ferreira, Silvia Helena Barem Rabenhorst

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In one paragraph

Article in Digestive diseases and sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Frontiers in oncology · 2020
    Article
  3. Article
  4. Article
  5. Helicobacter pylori in gastric carcinogenesis.World journal of gastrointestinal oncology · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Débora Menezes da CostaMolecular Genetics Laboratory, Department of Pathology and Forensic Medicine, School of Medicine, Federal University of Ceará, Street Coronel Nunes de Melo, 1315 - Rodolfo Teófilo, Fortaleza, Ceará, 60430-270, Brazil, debora_mcosta@hotmail.com.
Eliane Dos Santos Pereira
Isabelle Joyce de Lima Silva-Fernandes
Márcia Valéria Pitombeira Ferreira
Silvia Helena Barem Rabenhorst
Universidade Federal do Ceará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastric cancer results from a multifactorial process and is one of the most common causes of death worldwide. These tumors can arise in the distal stomach (non-cardia) and in the cardia region, presenting different characteristics and frequency of occurrence worldwide.

aimsTo search for differences between tumors of different locations that could explain the presence of cardia tumors, considering Helicobacter pylori strains and genetic polymorphisms. MATERIALS AND

methodsDNA was extracted from gastric adenocarcinoma tissue of 127 patients. Helicobacter pylori genes were detected by PCR, and polymorphisms by PCR-RFLP.

resultsMost of the tumors were located in non-cardia. The genotype 28152GA of XRCC1 showed an increase in risk of cardia tumors. In analysis performed considering gender, women carrying TNF-308GA genotype showed a decreased risk of non-cardia tumors, while in men the decreased risk of non-cardia tumors was associated with TNF-308GG genotype. Genotypes combinations showed that the SNPs RAD51 135G>C, XRCC3 18067C>T, and XRCC1 28152G>A had some combinations more frequent in cardia tumors, with an increased risk. Patients infected by cagE-positive strains presented a positive correlation with non-cardia tumors.

conclusionThe results showed some susceptibility differences between tumors of different locations. There was an increased risk relationship between three repair enzyme SNPs and cardia tumors, and the G allele of the cytokine gene TNF negatively influenced the development of non-cardia tumors. Helicobacter pylori strains seemed to be different in the cardia region, where they were less virulent than those located in the distal region of the stomach.

Indexed as

CardiaAdenocarcinomaAntigens, BacterialBacterial ProteinsDNA-Binding ProteinsFemaleGenes, BacterialGenotypeHelicobacter pyloriHumansMaleMiddle AgedPolymorphism, Restriction Fragment LengthRad51 RecombinaseSex FactorsStomach NeoplasmsAntigens, BacterialBacterial ProteinscagA protein, Helicobacter pyloriDNA-Binding ProteinsPicB protein, Helicobacter pyloriRAD51 protein, humanRad51 RecombinaseTumor Necrosis Factor-alphaVacA protein, Helicobacter pyloriX-ray Repair Cross Complementing Protein 1X-ray repair cross complementing protein 3XRCC1 protein, human

Identifiers

PMID25902748
OpenAlexW1989855462

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.