ArticleProceedings of the National Academy of Sciences of the United States of America2015
Unraveling functional significance of natural variations of a human galectin by glycodendrimersomes with programmable glycan surface.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 85 citations in OpenAlex.
- Coordination-cage-templated multivalent glycan arrays: effects of mixed-glycan composition and chain length on lectin binding.Chemical science · 2026Article
- Label-Free and Microplate-Based Dissection of Glycan-Virus Interactions Using Polymer-Tethered Glyconanoparticles.Small methods · 2025Article
- Galectin-8 modulates human osteoclast activity partly through isoform-specific interactions.Life science alliance · 2024Article
- Programmable Monodisperse Glyco-Multivalency Using Self-Assembled Coordination Cages as Scaffolds.ACS applied materials & interfaces · 2023Article
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- Selective synthesis ofFrontiers in chemistry · 2022Article
- Role of Globotriaosylceramide in Physiology and Pathology.Frontiers in molecular biosciences · 2022Review
- Imitating evolution's tinkering by protein engineering reveals extension of human galectin-7 activity.Histochemistry and cell biology · 2021Article
- Enhanced Concanavalin A Binding to Preorganized Mannose Nanoarrays in Glycodendrimersomes Revealed Multivalent Interactions.Angewandte Chemie (International ed. in English) · 2021Article
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- The SARS-COV-2 Spike Protein Binds Sialic Acids and Enables Rapid Detection in a Lateral Flow Point of Care Diagnostic Device.ACS central science · 2020Article
- Introducing affinity and selectivity into galectin-targeting nanoparticles with fluorinated glycan ligands.Chemical science · 2020Article
- How galectins have become multifunctional proteins.Histology and histopathology · 2020Review
- Bioactive Virus-Mimicking Nanovesicles From Dendrimersomes: A Novel Approach to Understanding SARS-CoV-2 Host-Interactions to Better Design Therapeutics.Frontiers in molecular biosciences · 2020Article
- The Impact of Natural Selection on the Evolution and Function of Placentally Expressed Galectins.Genome biology and evolution · 2019Article
- Encoding biological recognition in a bicomponent cell-membrane mimic.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Screening Libraries of Amphiphilic Janus Dendrimers Based on Natural Phenolic Acids to Discover Monodisperse Unilamellar Dendrimersomes.Biomacromolecules · 2019Article
- Double-Modified Glycopolymers from Thiolactones to Modulate Lectin Selectivity and Affinity.ACS macro letters · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surface-presented glycans (complex carbohydrates) are docking sites for adhesion/growth-regulatory galectins within cell-cell/matrix interactions. Alteration of the linker length in human galectin-8 and single-site mutation (F19Y) are used herein to illustrate the potential of glycodendrimersomes with programmable glycan displays as a model system to reveal the functional impact of natural sequence variations in trans recognition. Extension of the linker length slightly reduces lectin capacity as agglutinin and slows down aggregate formation at low ligand surface density. The mutant protein is considerably less active as agglutinin and less sensitive to low-level ligand presentation. The present results suggest that mimicking glycan complexity and microdomain occurrence on the glycodendrimersome surface can provide key insights into mechanisms to accomplish natural selectivity and specificity of lectins in structural and topological terms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.