ArticleProceedings of the National Academy of Sciences of the United States of America2015
Injury alters intrinsic functional connectivity within the primate spinal cord.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
53 citing papers in PubMed, 80 citations in OpenAlex.
- Early Detection of Neuroinflammation and White Matter Damage Following Dorsal Spinal Nerve Root Sectioning in a Nonhuman Primate Model.Magnetic resonance in medicine · 2026Article
- Functional magnetic resonance imaging insights into nociceptive signal processing network in rat lumbar spinal cord.Pain reports · 2026Article
- Anti-inflammatory treatment confirms rsfMRI and TSPO PET as biomarkers of functional connectivity and neuroinflammation in rat contusion spinal cord injuries.Scientific reports · 2026Article
- Assessment of Chronic Multi-Electrode Spinal Cord Electrical Stimulation and Electromyography Platform in Non-Human Primates.Biomedicines · 2026Article
- Relationships Between Intra-Spinal Resting-State Functional Connectivity and Electrophysiology Following Spinal Cord Injury.Human brain mapping · 2025Article
- AI-assisted 3D analysis of grasping and reaching behavior of squirrel monkeys during recovery from cervical spinal cord injury.Behavioural brain research · 2025Article
- EPISeg: Automated segmentation of the spinal cord on echo planar images using open-access multi-center data.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- The neural basis of resting-state fMRI functional connectivity in fronto-limbic circuits revealed by chemogenetic manipulation.Nature communications · 2024Article
- Characteristic BOLD signals are detectable in white matter of the spinal cord at rest and after a stimulus.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Spinal fMRI demonstrates segmental organisation of functionally connected networks in the cervical spinal cord: A test-retest reliability study.Human brain mapping · 2024Article
- Lumbosacral spinal cord functional connectivity at rest: From feasibility to reliability.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Spinal Cord fMRI: A New Window into the Central Nervous System.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2023Review
- Longitudinal multiparametric MRI of traumatic spinal cord injury in animal models.Magnetic resonance imaging · 2023Review
- Reliability of resting-state functional connectivity in the human spinal cord: Assessing the impact of distinct noise sources.NeuroImage · 2023Article
- Detection and characterization of resting state functional networks in squirrel monkey brain.Cerebral cortex communications · 2023Article
- Phenotypes of Motor Deficit and Pain after Experimental Spinal Cord Injury.Bioengineering (Basel, Switzerland) · 2022Article
- Design and construction of an interchangeable RF coil system for rodent spinal cord MR imaging at 9.4 T.Magnetic resonance imaging · 2021Article
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- Spontaneous neural synchrony links intrinsic spinal sensory and motor networks during unconsciousness.eLife · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 4 countries.
Funding
Abstract
Recent demonstrations of correlated low-frequency MRI signal variations between subregions of the spinal cord at rest in humans, similar to those found in the brain, suggest that such resting-state functional connectivity constitutes a common feature of the intrinsic organization of the entire central nervous system. We report our detection of functional connectivity within the spinal cords of anesthetized squirrel monkeys at rest and show that the strength of connectivity within these networks is altered by the effects of injuries. By quantifying the low-frequency MRI signal correlations between different horns within spinal cord gray matter, we found distinct functional connectivity relationships between the different sensory and motor horns, a pattern that was similar to activation patterns evoked by nociceptive heat or tactile stimulation of digits. All horns within a single spinal segment were functionally connected, with the strongest connectivity occurring between ipsilateral dorsal and ventral horns. Each horn was strongly connected to the same horn on neighboring segments, but this connectivity reduced drastically along the spinal cord. Unilateral injury to the spinal cord significantly weakened the strength of the intrasegment horn-to-horn connectivity only on the injury side and in slices below the lesion. These findings suggest resting-state functional connectivity may be a useful biomarker of functional integrity in injured and recovering spinal cords.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.