ArticleBiophysical journal2015
Effects of cardiolipin on membrane morphology: a Langmuir monolayer study.
Article in Biophysical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- The Spectrum of Mitochondrial Ultrastructural Defects in Mitochondrial Myopathy.Scientific reports · 2016Pooled it
- The physicochemical design, structure and permeability of the JCVI-syn3A minimal cell membrane.Nature communications · 2026Article
- Polyproline-Polyornithine Diblock Copolymers with Inherent Mitochondria Tropism.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Physicochemical Characteristics of Model Membranes Composed ofMembranes · 2023Article
- The Influence of Polysaccharides/TiOMolecules (Basel, Switzerland) · 2022Article
- Mitochondrial membrane models built from native lipid extracts: Interfacial and transport properties.Frontiers in molecular biosciences · 2022Article
- Unraveling cardiolipin-induced conformational change of cytochrome c through H/D exchange mass spectrometry and quartz crystal microbalance.Scientific reports · 2021Article
- Acylcarnitines at the Membrane Surface: Insertion Parameters for a Mitochondrial Leaflet Model.Biophysical journal · 2020Article
- Cardiolipin-Dependent Properties of Model Mitochondrial Membranes from Molecular Simulations.Biophysical journal · 2019Article
- The role of cardiolipin concentration and acyl chain composition on mitochondrial inner membrane molecular organization and function.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2019Review
- Molecular Dynamics Modeling of the Interaction of Cationic Fluorescent Lipid Peroxidation-Sensitive Probes with the Mitochondrial Membrane.Doklady. Biochemistry and biophysics · 2019Article
- Cholesterol and Cardiolipin Importance in Local Anesthetics-Membrane Interactions: The Langmuir Monolayer Study.The Journal of membrane biology · 2019Article
- Distinct membrane properties are differentially influenced by cardiolipin content and acyl chain composition in biomimetic membranes.Biochimica et biophysica acta. Biomembranes · 2017Article
- Known unknowns of cardiolipin signaling: The best is yet to come.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2017Review
- Lipid-Loving ANTs: Molecular Simulations of Cardiolipin Interactions and the Organization of the Adenine Nucleotide Translocase in Model Mitochondrial Membranes.Biochemistry · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiolipin (CL) is a complex phospholipid that is specifically found in mitochondria. Owing to the association of the CL levels with mitochondrial physiopathology such as in Parkinson's disease, we study the molecular effect of CL on membrane organization using model Langmuir monolayer, fluorescence microscopy, and x-ray reflectivity. We find that the liquid-expanded phase in membranes increases with increasing CL concentration, indicating an increase in the elasticity of the mixed membrane. The Gibbs excess free energy of mixing indicates that the binary monolayer composed of CL and DPPC is most thermodynamically stable at ΦCL = 10 mol%, and the stability is enhanced when the surface pressure is increased. Additionally, when ΦCL is small, the expansion of the membrane with increasing CL content was slower at higher surface pressure. These abnormal results are indicative of a folding structure being present before a collapsing structure, which was confirmed by using fluorescence microscopy and was characterized by using x-ray reflectivity with the electron density profile along the membrane's surface normal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.