ArticlePloS one2015
Comparative proteomic analysis of the molecular responses of mouse macrophages to titanium dioxide and copper oxide nanoparticles unravels some toxic mechanisms for copper oxide nanoparticles in macrophages.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 65 citations in OpenAlex.
- Copper oxide nanoparticles: from EU-regulatory landscape and mechanistic toxicity towards a cuproptosis-linked adverse outcome pathway.Archives of toxicology · 2026Review
- Biogenic Silver Nanoparticles for Targeted Cancer Therapy and Enhancing Photodynamic Therapy.Cells · 2023Review
- Repeated Exposure of Macrophages to Synthetic Amorphous Silica Induces Adaptive Proteome Changes and a Moderate Cell Activation.Nanomaterials (Basel, Switzerland) · 2022Article
- Immediate and Sustained Effects of Cobalt and Zinc-Containing Pigments on Macrophages.Frontiers in immunology · 2022Article
- Evaluation of the immunomodulatory effects of cobalt, copper and magnesium ions in a pro inflammatory environment.Scientific reports · 2021Article
- Multiparametric Profiling of Engineered Nanomaterials: Unmasking the Surface Coating Effect.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- How Reversible Are the Effects of Fumed Silica on Macrophages? A Proteomics-Informed View.Nanomaterials (Basel, Switzerland) · 2020Article
- Review
- Influences of Nanoparticles Characteristics on the Cellular Responses: The Example of Iron Oxide and Macrophages.Nanomaterials (Basel, Switzerland) · 2020Article
- Article
- ZnO and TiO2 nanoparticles alter the ability of Bacillus subtilis to fight against a stress.PloS one · 2020Article
- Effects of Iron Oxide Nanoparticles (γ-FeInternational journal of molecular sciences · 2019Article
- Article
- Food additives can act as triggering factors in celiac disease: Current knowledge based on a critical review of the literature.World journal of clinical cases · 2019Review
- Mass spectrometry-based proteomics for system-level characterization of biological responses to engineered nanomaterials.Analytical and bioanalytical chemistry · 2018Review
- Impact of nanoparticles on the Bacillus subtilis (3610) competence.Scientific reports · 2018Article
- Role of omics techniques in the toxicity testing of nanoparticles.Journal of nanobiotechnology · 2017Review
- Omics Approaches for Identifying Physiological Adaptations to Genome Instability in Aging.International journal of molecular sciences · 2017Review
- Antibacterial and Biocompatible Titanium-Copper Oxide Coating May Be a Potential Strategy to Reduce Periprosthetic Infection: An In Vitro Study.Clinical orthopaedics and related research · 2017Article
- Copper oxide nanoparticle toxicity profiling using untargeted metabolomics.Particle and fibre toxicology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Titanium dioxide and copper oxide nanoparticles are more and more widely used because of their catalytic properties, of their light absorbing properties (titanium dioxide) or of their biocidal properties (copper oxide), increasing the risk of adverse health effects. In this frame, the responses of mouse macrophages were studied. Both proteomic and targeted analyses were performed to investigate several parameters, such as phagocytic capacity, cytokine release, copper release, and response at sub toxic doses. Besides titanium dioxide and copper oxide nanoparticles, copper ions were used as controls. We also showed that the overall copper release in the cell does not explain per se the toxicity observed with copper oxide nanoparticles. In addition, both copper ion and copper oxide nanoparticles, but not titanium oxide, induced DNA strands breaks in macrophages. As to functional responses, the phagocytic capacity was not hampered by any of the treatments at non-toxic doses, while copper ion decreased the lipopolysaccharide-induced cytokine and nitric oxide productions. The proteomic analyses highlighted very few changes induced by titanium dioxide nanoparticles, but an induction of heme oxygenase, an increase of glutathione synthesis and a decrease of tetrahydrobiopterin in response to copper oxide nanoparticles. Subsequent targeted analyses demonstrated that the increase in glutathione biosynthesis and the induction of heme oxygenase (e.g. by lovastatin/monacolin K) are critical for macrophages to survive a copper challenge, and that the intermediates of the catecholamine pathway induce a strong cross toxicity with copper oxide nanoparticles and copper ions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.