ArticlePloS one2015
Identification and Molecular Characterisation of a Novel Mu-Like Bacteriophage, SfMu, of Shigella flexneri.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Bacteriophage as a potential biotherapeutics to combat present-day crisis of multi-drug resistant pathogens.Heliyon · 2024Review
- Characterization of Mu-LikeMicrobiology spectrum · 2023Article
- Unexplored diversity and ecological functions of transposable phages.The ISME journal · 2023Article
- Transcriptional analysis in bacteriophage Fc02 ofFrontiers in microbiology · 2023Article
- Genome Study of a Novel Virulent Phage vB_SspS_KASIA and Mu-like Prophages ofInternational journal of molecular sciences · 2021Article
- Diversity and characterization of temperate bacteriophages induced in Pasteurella multocida from different host species.BMC microbiology · 2021Article
- Structure and genetics of Escherichia coli O antigens.FEMS microbiology reviews · 2020Review
- Ecology, Structure, and Evolution ofAnnual review of virology · 2020Review
- Phage tail fibre assembly proteins employ a modular structure to drive the correct folding of diverse fibres.Nature microbiology · 2019Article
- Understanding and Exploiting Phage-Host Interactions.Viruses · 2019Review
- Complete Genome Sequence Analysis and Characterization of Selected Iron Regulation Genes ofGenes · 2019Article
- Bacteriophage application for biocontrollingJournal of food science and technology · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
S. flexneri is the leading cause of bacillary dysentery in the developing countries. Several temperate phages originating from this host have been characterised. However, all S. flexneri phages known to date are lambdoid phages, which have the ability to confer the O-antigen modification of their host. In this study, we report the isolation and characterisation of a novel Mu-like phage from a serotype 4a strain of S. flexneri. The genome of phage SfMu is composed of 37,146 bp and is predicted to contain 55 open reading frames (orfs). Comparative genome analysis of phage SfMu with Mu and other Mu-like phages revealed that SfMu is closely related to phage Mu, sharing >90% identity with majority of its proteins. Moreover, investigation of phage SfMu receptor on the surface of the host cell revealed that the O-antigen of the host serves as the receptor for the adsorption of phage SfMu. This study also demonstrates pervasiveness of SfMu phage in S. flexneri, by identifying complete SfMu prophage strains of serotype X and Y, and remnants of SfMu in strains belonging to 4 other serotypes, thereby indicating that transposable phages in S. flexneri are not uncommon. The findings of this study contribute an advance in our current knowledge of S. flexneri phages and will also play a key role in understanding the evolution of S. flexneri.
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