ArticlePloS one2015
Integrative omics analysis of rheumatoid arthritis identifies non-obvious therapeutic targets.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 61 citations in OpenAlex.
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- Human pain transcriptomics: lessons learned so far.Pain reports · 2026Review
- Genomic and cellular context-dependent expression of the human ELMO1 gene transcript variants.Gene · 2025Article
- The Identification of Novel Therapeutic Biomarkers in Rheumatoid Arthritis: A Combined Bioinformatics and Integrated Multi-Omics Approach.International journal of molecular sciences · 2025Article
- Methotrexate promotes the release of granulocyte-macrophage colony-stimulating factor from rheumatoid arthritis fibroblast-like synoviocytes via autocrine interleukin-1 signaling.Arthritis research & therapy · 2024Article
- ELMO1 ameliorates intestinal epithelial cellular senescence via SIRT1/p65 signaling in inflammatory bowel disease-related fibrosis.Gastroenterology report · 2024Article
- Article
- Caspase-8 Variant G Regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Aggressive Behavior.ACR open rheumatology · 2022Article
- A Final Frontier in Environment-Genome Interactions? Integrated, Multi-Omic Approaches to Predictions of Non-Communicable Disease Risk.Frontiers in genetics · 2022Review
- Article
- Association analysis of juvenile idiopathic arthritis genetic susceptibility factors in Estonian patients.Clinical rheumatology · 2021Article
- Cell-Free DNA in Rheumatoid Arthritis.International journal of molecular sciences · 2021Review
- Adenosine deaminase modulates metabolic remodeling and orchestrates joint destruction in rheumatoid arthritis.Scientific reports · 2021Article
- Multiomics landscape of synovial fibroblasts in rheumatoid arthritis.Inflammation and regeneration · 2021Review
- Why remission is not enough: underlying disease mechanisms in RA that prevent cure.Nature reviews. Rheumatology · 2021Review
- Novel Insights Into Rheumatoid Arthritis Through Characterization of Concordant Changes in DNA Methylation and Gene Expression in Synovial Biopsies of Patients With Differing Numbers of Swollen Joints.Frontiers in immunology · 2021Observational
- Host engulfment pathway controls inflammation in inflammatory bowel disease.The FEBS journal · 2020Article
- Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes.Nature reviews. Rheumatology · 2020Review
- A phenotypic and genomics approach in a multi-ethnic cohort to subtype systemic lupus erythematosus.Nature communications · 2019Article
- A noncanonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritis.Nature immunology · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Identifying novel therapeutic targets for the treatment of disease is challenging. To this end, we developed a genome-wide approach of candidate gene prioritization. We independently collocated sets of genes that were implicated in rheumatoid arthritis (RA) pathogenicity through three genome-wide assays: (i) genome-wide association studies (GWAS), (ii) differentially expression in RA fibroblast-like synoviocytes (FLS), and (iii) differentially methylation in RA FLS. Integrated analysis of these complementary data sets identified a significant enrichment of multi-evidence genes (MEGs) within pathways relating to RA pathogenicity. One MEG is Engulfment and Cell Motility Protein-1 (ELMO1), a gene not previously considered as a therapeutic target in RA FLS. We demonstrated in RA FLS that ELMO1 is: (i) expressed, (ii) promotes cell migration and invasion, and (iii) regulates Rac1 activity. Thus, we created links between ELMO1 and RA pathogenicity, which in turn validates ELMO1 as a potential RA therapeutic target. This study illustrated the power of MEG-based approaches for therapeutic target identification.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.