ArticleNanoscale2015
NanoCluster Beacons as reporter probes in rolling circle enhanced enzyme activity detection.
Article in Nanoscale, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Role of nanoclusters in the design and development of novel strategies for diagnosis and treatment of infectious diseases.Nanoscale advances · 2026Review
- An Atom-Precise Understanding of DNA-Stabilized Silver Nanoclusters.Accounts of chemical research · 2024Review
- A non-FRET DNA reporter that changes fluorescence colour upon nuclease digestion.Nature nanotechnology · 2024Article
- Article
- Massively Parallel Selection of NanoCluster Beacons.Advanced materials (Deerfield Beach, Fla.) · 2022Article
- Structure and luminescence of DNA-templated silver clusters.Nanoscale advances · 2021Review
- Development of dual-emission cluster of Ag atoms for genetically modified organisms detection.Mikrochimica acta · 2020Article
- Footprints of Nanoscale DNA-Silver Cluster ChromophoresACS nano · 2019Article
- Split Dapoxyl Aptamer for Sequence-Selective Analysis of Nucleic Acid Sequence Based Amplification Amplicons.Analytical chemistry · 2019Article
- The role of spacer sequence in modulating turn-on fluorescence of DNA-templated silver nanoclusters.Nucleic acids research · 2018Article
- LNA Thymidine Monomer Enables Differentiation of the Four Single-Nucleotide Variants by Melting Temperature.Journal of the American Chemical Society · 2017Article
- Split Spinach Aptamer for Highly Selective Recognition of DNA and RNA at Ambient Temperatures.Chembiochem : a European journal of chemical biology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
As a newly developed assay for the detection of endogenous enzyme activity at the single-catalytic-event level, Rolling Circle Enhanced Enzyme Activity Detection (REEAD) has been used to measure enzyme activity in both single human cells and malaria-causing parasites, Plasmodium sp. Current REEAD assays rely on organic dye-tagged linear DNA probes to report the rolling circle amplification products (RCPs), the cost of which may hinder the widespread use of REEAD. Here we show that a new class of activatable probes, NanoCluster Beacons (NCBs), can simplify the REEAD assays. Easily prepared without any need for purification and capable of large fluorescence enhancement upon hybridization, NCBs are cost-effective and sensitive. Compared to conventional fluorescent probes, NCBs are also more photostable. As demonstrated in reporting the human topoisomerases I (hTopI) cleavage-ligation reaction, the proposed NCBs suggest a read-out format attractive for future REEAD-based diagnostics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.