ArticleJournal of the American Academy of Child and Adolescent Psychiatry2015
Pathways to suicide-related behavior in offspring of mothers with depression: the role of offspring psychopathology.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Pooled it
- Exposure to parental psychopathology and offspring's risk of suicide-related thoughts and behaviours: a systematic review.Epidemiology and psychiatric sciences · 2019Pooled it
- Social environmental risk factors for persistent self-harm in early-to-middle adolescence: data from the Tokyo Teen Cohort study.Child and adolescent psychiatry and mental health · 2026Article
- Psychiatric outcomes and long-term school and work-related disability in offspring of parents with depression and treatment-resistant depression.Social psychiatry and psychiatric epidemiology · 2026Article
- Maternal History of Major Depression, Social Support from Peers, and Children's Risk for Self-Injurious Thoughts and Behaviors.Research on child and adolescent psychopathology · 2025Article
- Parental Mental Health and Suicidal Behavior as Predictors of Adolescent Suicidal Ideation and Attempts: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- The incidence and risk factors of depression across six time points in the perinatal period: a prospective study in China.Frontiers in medicine · 2024Article
- Co-Developmental Trajectories of Parental Psychological Distress and Child Internalizing and Externalizing Problems in Childhood and Adolescence: Associations with Self-Harm and Suicide Attempts.Research on child and adolescent psychopathology · 2023Article
- Association of parental death and illness with offspring suicidal ideation: cross-sectional study in a large cohort of university students.Social psychiatry and psychiatric epidemiology · 2022Article
- Developmental trajectories of childhood symptoms of hyperactivity/inattention and suicidal behavior during adolescence.European child & adolescent psychiatry · 2020Article
- Depressive symptoms measured using the Edinburgh Postnatal Depression Scale in mothers and partners in the ALSPAC Study: A data note.Wellcome open research · 2020Article
- Association of birth order with adolescent mental health and suicide attempts: a population-based longitudinal study.European child & adolescent psychiatry · 2019Article
- Characterizing Developmental Trajectories and the Role of Neuropsychiatric Genetic Risk Variants in Early-Onset Depression.JAMA psychiatry · 2019Article
- Exposure to maternal depressive symptoms in childhood and adolescent suicide-related thoughts and attempts: mediation by child psychiatric symptoms.Epidemiology and psychiatric sciences · 2019Article
- Exposure to maternal depressive symptoms in childhood and suicide-related thoughts and attempts in Canadian youth: test of effect-modifying factors.Social psychiatry and psychiatric epidemiology · 2019Article
- Attendance of routine childcare visits in primary care for children of mothers with depression: a nationwide population-based cohort study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2018Article
- Classification of facial expressions of emotion and risk for suicidal ideation in children of depressed mothers: Evidence from cross-sectional and prospective analyses.Journal of affective disorders · 2016Article
- Cognitive vulnerabilities and development of suicidal thinking in children of depressed mothers: A longitudinal investigation.Psychiatry research · 2016Article
- Explaining risk for suicidal ideation in adolescent offspring of mothers with depression.Psychological medicine · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveOffspring of mothers with depression are a high-risk group for the development of suicide-related behavior. These offspring are therefore a priority for preventive interventions; however, pathways contributing to risk, including specific aspects of offspring psychopathology, remain unclear. The aim of this study was to examine whether offspring symptoms of major depressive disorder (MDD), generalized anxiety disorder (GAD), disruptive behavior disorder (DBD), attention-deficit/hyperactivity disorder (ADHD), and alcohol abuse independently mediate the association between maternal depression and offspring suicide-related behavior.
methodData were used from a population-based birth cohort, the Avon Longitudinal Study of Parents and Children (ALSPAC). Three distinct classes of depression symptoms across the mothers' first 11 years of their child's life were identified (minimal, moderate, chronic-severe). Offspring psychopathology was assessed at age 15 years and suicide-related behavior at age 16 years. Data were analyzed using structural equation modeling.
resultsThere was evidence for increased risk of suicidal ideation in offspring of mothers with chronic-severe depression symptoms in comparison to offspring of mothers with minimal symptoms (odds ratio = 3.04, 95% CI = 2.19, 4.21). This association was independently mediated by offspring MDD, GAD, and DBD symptoms. The same mechanisms were found for offspring of mothers with moderate depression symptoms over time. Results were similar for offspring suicide attempt except for additional evidence of an indirect effect through offspring ADHD symptoms.
conclusionFindings highlight that suicide prevention efforts in offspring of mothers with depression should not only be targeted at offspring with MDD; it is also important to consider offspring with other forms of psychopathology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.