Evidence map›Paper›PMID 25901477›Full record

Trial reportJournal of opioid management

Opioid treatment of experimental pain activates nuclear factor-κB.

Peggy Compton, Charles Griffis, Elizabeth Crabb Breen, Matthew Torrington, Ryan Sadakane, Eshetu Tefera, Michael R Irwin

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of opioid management. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01210066 (Pain, Opioids and Pro-Inflammatory Immune Responses), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01210066 phase1terminatednot on this map

Pain, Opioids and Pro-Inflammatory Immune Responses

TypeinterventionalSponsorUniversity of California, Los AngelesRan2010 to 2012Enrolled21ConditionsPro-inflammatory Activity, Immunologic Activity AlterationArmsFentanyl, Cold pressor test, Fentanyl plus cold pressor test
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Peggy ComptonDepartment of Nursing, School of Nursing and Health Studies, Georgetown University, Washington, DC.
Charles GriffisDepartment of Anesthesiology, University of California, Los Angeles, Los Angeles, California.
Elizabeth Crabb BreenCousins Center for Psychoneuroimmunology, Semel Institute for Neurosciences, University of California, Los Angeles, Los Angeles, California.
Matthew TorringtonDepartment of Family Medicine, University of California, Los Angeles, Los Angeles, California.
Ryan SadakaneCousins Center for Psychoneuroimmunology, Semel Institute for Neurosciences, University of California, Los Angeles, Los Angeles, California.
Eshetu TeferaDepartment of Biostatistics and Epidemiology, MedStar Health Research Institute, Columbia, Maryland.
Michael R IrwinCousins Center for Psychoneuroimmunology, Semel Institute for Neurosciences, University of California, Los Angeles, Los Angeles, California.
University of California, Los Angeles · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Georgetown-Howard Universities Center for Clinical and Translational Science (GHUUL1RR031975 · NCRR · GEORGETOWN UNIVERSITY · PI VERBALIS, JOSEPH G · 2010 to 2011
$14.6M
UCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MOORE, ALISON AHERN · 2006 to 2017
$9.8M
Aging: Sleep and Inflammatory Mechanisms in Depression PreventionR01AG026364 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2005 to 2015
$5.8M
Sleep, Inflamation, and Depression Occurrence in Breast Cancer SurvivorsR01CA160245 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2012 to 2016
$3.9M
Chronic Moderate Sleep Restriction in Older Long and Older Average SleepersR01HL095799 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI IRWIN, MICHAEL R, JEAN-LOUIS, GIRARDIN · 2011 to 2015
$3.8M
Mechanisms of Sleep Disruption HyperalgesiaR01DA032922 · NIDA · JOHNS HOPKINS UNIVERSITY · PI IRWIN, MICHAEL R, SMITH, MICHAEL T · 2012 to 2016
$2.7M
Tai Chi Effects on Chronic Insomnia in Breast Cancer Survivors: Immune MechanismsR01CA119159 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2006 to 2010
$2.2M
Subjective Social Isolation and Sleep Disturbances: Inflammatory Mechanisms in AgR01AG034588 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2009 to 2013
$1.9M
Pain, Opioids And Pro-Inflammatory Immune ResponsesR21DA027558 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COMPTON, PEGGY A · 2009 to 2010
$422k
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCI NIH HHS R01 CA119159NCI NIH HHS R01-CA119159NCI NIH HHS R01 CA160245NCI NIH HHS R01 CA160245-01NCRR NIH HHS UL1 RR031975NHLBI NIH HHS R01 HL095799NHLBI NIH HHS R01HL095799NIA NIH HHS P30 AG028748NIA NIH HHS P30-AG028748NIA NIH HHS R01 AG026364NIA NIH HHS R01-AG026364NIA NIH HHS R01 AG034588NIA NIH HHS R01-AG034588NIDA NIH HHS R01 DA032922NIDA NIH HHS R01 DA032922-01NIDA NIH HHS R21 DA027558NIDA NIH HHS R21-DA027558-01
6 · The paper itself

Abstract

objectiveTo determine the independent and combined effects of pain and opioids on the activation of an early marker of inflammation, nuclear factor-κB (NF-κB).

designNF-κB activation was compared within-subjects following four randomly ordered experimental sessions of opioid-only (intravenous fentanyl 1 μg/kg), painonly (cold-pressor), opioid + pain, and a resting condition.

settingUniversity General Clinical Research Center.

participantsTwenty-one (11 female) healthy controls.

interventionsFollowing exposure to treatment (fentanyl administration and/or cold-pressor pain), blood samples for NF-κB analysis were obtained.

main outcome measuresIntracellular levels of activated NF-κB, in unstimulated and stimulated peripheral blood mononuclear cells at 15 and 30 minutes.

resultsNeither pain nor opioid administration alone effected NF-κB levels in cell populations; however, the combination of treatments induced significant increases of NF-κB in stimulated peripheral blood mononuclear cell, lymphocytes, and monocytes.

conclusionsThe combination of acute pain with opioids, as occurs in clinical situations, activates a key transcription factor involved in proinflammatory responses.

Indexed as

Analgesics, OpioidFentanylNF-kappa BPainAdultFemaleFollow-Up StudiesHealthy VolunteersHumansInjections, IntravenousMaleMonocytesSignal TransductionAnalgesics, OpioidFentanylNF-kappa B

Identifiers

PMID25901477
PMCPMC4507428
OpenAlexW2110012782

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.