ArticleProceedings of the National Academy of Sciences of the United States of America2015
Organogenesis in deep time: A problem in genomics, development, and paleontology.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- The emergence ofFrontiers in cell and developmental biology · 2025Article
- Article
- Understanding the evolution of viviparity using intraspecific variation in reproductive mode and transitional forms of pregnancy.Biological reviews of the Cambridge Philosophical Society · 2022Article
- Problems in Fish-to-Tetrapod Transition: Genetic Expeditions Into Old Specimens.Frontiers in cell and developmental biology · 2018Review
- Perspectives on the history of evo-devo and the contemporary research landscape in the genomics era.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Approaches to Macroevolution: 1. General Concepts and Origin of Variation.Evolutionary biology · 2017Article
- Distal Limb Patterning Requires Modulation of cis-Regulatory Activities by HOX13.Cell reports · 2016Article
- Developmental origin of the clavicle, and its implications for the evolution of the neck and the paired appendages in vertebrates.Journal of anatomy · 2016Article
- Regulatory evolution of Tbx5 and the origin of paired appendages.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Cis-regulatory programs in the development and evolution of vertebrate paired appendages.Seminars in cell & developmental biology · 2016Review
- Fossil hominin shoulders support an African ape-like last common ancestor of humans and chimpanzees.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The future of the fossil record: Paleontology in the 21st century.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The fossil record is a unique repository of information on major morphological transitions. Increasingly, developmental, embryological, and functional genomic approaches have also conspired to reveal evolutionary trajectory of phenotypic shifts. Here, we use the vertebrate appendage to demonstrate how these disciplines can mutually reinforce each other to facilitate the generation and testing of hypotheses of morphological evolution. We discuss classical theories on the origins of paired fins, recent data on regulatory modulations of fish fins and tetrapod limbs, and case studies exploring the mechanisms of digit loss in tetrapods. We envision an era of research in which the deep history of morphological evolution can be revealed by integrating fossils of transitional forms with direct experimentation in the laboratory via genome manipulation, thereby shedding light on the relationship between genes, developmental processes, and the evolving phenotype.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.