ArticleWorld journal of gastrointestinal endoscopy2015
Re-bleeding events in patients with obscure gastrointestinal bleeding after negative capsule endoscopy.
Article in World journal of gastrointestinal endoscopy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Long-Term Outcomes and Rebleeding Risk Factors in Suspected Small Bowel Bleeding: A Study Based on the Modified Saurin Classification.Digestive diseases and sciences · 2026Observational
- Risk factors of anastomosis-related difficult endoscopic retrograde cholangiopancreatography following endoscopic ultrasound-guided gastro-gastrostomy using a standardized protocol (with video).Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2023Observational
- Prediction models for recurrence in patients with small bowel bleeding.World journal of clinical cases · 2023Review
- Article
- Diagnostic yield of inpatient capsule endoscopy.BMC gastroenterology · 2022Article
- Clinical Outcomes between P1 and P0 Lesions for Obscure Gastrointestinal Bleeding with Negative Computed Tomography and Capsule Endoscopy.Diagnostics (Basel, Switzerland) · 2021Article
- Negative Video Capsule Endoscopy Had a High Negative Predictive Value for Small Bowel Lesions, but Diagnostic Capability May Be Lower in Young Patients with Overt Bleeding.Canadian journal of gastroenterology & hepatology · 2021Article
- A pilot trial of Convolution Neural Network for automatic retention-monitoring of capsule endoscopes in the stomach and duodenal bulb.Scientific reports · 2020Article
- Re-bleeding and its predictors after capsule endoscopy in patients with obscure gastrointestinal bleeding in long-term follow-up.BMC gastroenterology · 2019Article
- Capsule endoscopy in Portugal.Annals of translational medicine · 2017Article
- Long-term effects of video capsule endoscopy in the management of obscure gastrointestinal bleeding.Annals of translational medicine · 2017Review
- What is the impact of capsule endoscopy in the long term period?World journal of gastrointestinal endoscopy · 2016Article
- The Role of Capsule Endoscopy in Patients with Obscure Gastrointestinal Bleeding.Clinical endoscopy · 2016Review
- Diagnostic and therapeutic considerations for obscure gastrointestinal bleeding in patients with chronic kidney disease.Annals of gastroenterologyReview
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate long-term re-bleeding events after a negative capsule endoscopy in patients with obscure gastrointestinal bleeding (OGIB) and the risk factors associated with the procedure.
methodsPatients referred to Hospital Egas Moniz (Lisboa, Portugal) between January 2006 and October 2012 with OGIB and a negative capsule endoscopy were retrospectively analyzed. The following study variables were included: demographic data, comorbidities, bleeding-related drug use, hemoglobin level, indication for capsule endoscopy, post procedure details, work-up and follow-up. Re-bleeding rates and associated factors were assessed using a Cox proportional hazard analysis. The Kaplan-Meier method was used to estimate the cumulative incidence of re-bleeding at 1, 3 and 5 years, and the differences between factors were evaluated.
resultsThe study population consisted of 640 patients referred for OGIB investigation. Wireless capsule endoscopy was deemed negative in 113 patients (17.7%). A total of 64.6% of the population was female, and the median age was 69 years. The median follow-up was forty-eight months (interquartile range 24-60). Re-bleeding occurred in 27.4% of the cases. The median time to re-bleeding was fifteen months (interquartile range 2-33). In 22.6% (n = 7) of the population, small-bowel angiodysplasia was identified as the culprit lesion. A univariate analysis showed that age > 65 years old, chronic kidney disease, aortic stenosis, anticoagulant use and overt OGIB were risk factors for re-bleeding; however, on a multivariate analysis, there were no risk factors for re-bleeding. The cumulative risk of re-bleeding at 1, 3 and 5 years of follow-up was 12.9%, 25.6% and 31.5%, respectively. Patients who presented with overt OGIB tended to re-bleed sooner (median time for re-bleeding: 8.5 mo vs 22 mo).
conclusionPatients with OGIB despite a negative capsule endoscopy have a significant re-bleeding risk; therefore, these patients require an extended follow-up strategy.
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