ArticleIranian journal of pharmaceutical research : IJPR2015
In-vitro and In-vivo Evaluation of Silymarin Nanoliposomes against Isolated Methicillin-resistant Staphylococcus aureus.
Article in Iranian journal of pharmaceutical research : IJPR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Silybum marianum against multidrug-resistant bacterial pathogens: mechanisms of action, synergistic therapy, nanoformulations, and clinical translation.Archives of microbiology · 2026Review
- Advances in phytochemical-derived nanotherapeutics for multimodal eradication of multidrug-resistantFrontiers in pharmacology · 2026Review
- Synergistic effects of herbal extracts and nanoparticles in skin damage repair: A comprehensive review.Avicenna journal of phytomedicine · 2026Review
- Encapsulation ofACS applied materials & interfaces · 2024Article
- Unlocking the potential of flavonoid-infused drug delivery systems for diabetic wound healing with a mechanistic exploration.Inflammopharmacology · 2024Review
- Ultrasound assisted extraction and liposome encapsulation of olive leaves and orange peels: How to transform biomass waste into valuable resources with antimicrobial activity.Ultrasonics sonochemistry · 2024Article
- Nanobiosystems for Antimicrobial Drug-Resistant Infections.Nanomaterials (Basel, Switzerland) · 2021Review
- Microfluidization trends in the development of nanodelivery systems and applications in chronic disease treatments.International journal of nanomedicine · 2018Review
- Natural product-based nanomedicines for wound healing purposes: therapeutic targets and drug delivery systems.International journal of nanomedicine · 2018Review
- Nanoliposomal artemisinin for the treatment of murine visceral leishmaniasis.International journal of nanomedicine · 2017Article
- Silymarin: A Novel Natural Agent to Restore Defective Pancreatic β Cells in Streptozotocin (STZ)-induced Diabetic Rats.Iranian journal of pharmaceutical research : IJPR · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staphylococcus aureus is an opportunistic pathogen and remains a common cause of burn wound infections. Different studies have shown that entrapment of plant-derived compounds into liposomes could increase their anti-Staphylococcus aureus activity. Silymarin is the bioactive extract from the known plant Silybum marianum L. The objective of this study was to evaluate efficacy of silymarin in free and nanoliposomal forms against isolated methicillin-resistant Staphylococcus aureus (MRSA) strain. Silymarin-loaded nanoliposomes were prepared by extrusion method. The minimum inhibitory concentrations (MICs) of silymarin in free and nanoliposomal forms against MRSA were determined by broth dilution method. The killing rate of free and nanoliposomal forms of silymarin were analyzed. Ultimately, in-vivo therapeutic efficacy of nanoliposomes in burned mice infected by isolated MRSA was examined. The MICs of free and nanoliposomal forms of silymarin against isolated strain were 500 and 125 mg/L, respectively. The killing rate of silymarin-loaded nanoliposomes was higher than those of free silymarin. Topically treatment by silymarin in free and nanoliposomal forms resulted in almost 20 and 100% survival rates, respectively. The results suggest that silymarin-loaded nanoliposomes may provide a basis for future treatment of MRSA infections.
Indexed as
Identifiers
25901172PMC4403081What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.