ArticleIranian journal of pharmaceutical research : IJPR2015
Screening of different extracts from artemisia species for their potential antimalarial activity.
Article in Iranian journal of pharmaceutical research : IJPR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- From Traditional Use to Modern Evidence: The Medicinal Chemistry of Antimalarials from GenusMini reviews in medicinal chemistry · 2025Review
- Isolation of potent antileishmanial agents fromJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2023Article
- Secondary Metabolites Isolated fromMetabolites · 2023Review
- Antiplasmodial Properties of Aqueous and Ethanolic Extracts of Ten Herbal Traditional Recipes Used in Thailand againstTropical medicine and infectious disease · 2022Article
- Wild Egyptian medicinal plants show in vitro and in vivo cytotoxicity and antimalarial activities.BMC complementary medicine and therapies · 2022Article
- Comparison of the cytotoxic effects of different fractions ofResearch in pharmaceutical sciences · 2020Article
- Isolation of Two Isochlorogenic Acid Isomers from Phenolic Rich Fraction ofIranian journal of pharmaceutical research : IJPR · 2020Article
- Screening of Anti-Malarial Activity of Different Extracts Obtained from Three Species ofIranian journal of pharmaceutical research : IJPR · 2018Article
- Protective effects of fractions from Artemisia biennis hydro-ethanolic extract against doxorubicin-induced oxidative stress and apoptosis in PC12 cells.Iranian journal of basic medical sciences · 2016Article
- Evaluation of antioxidant and cytoprotective activities of Artemisia ciniformis extracts on PC12 cells.Iranian journal of basic medical sciences · 2016Article
- Flavonoids and Sesquiterpene Lactones fromEvidence-based complementary and alternative medicine : eCAM · 2016Article
- Evaluation of In Vitro Antimalarial Activity of Different Extracts ofIranian journal of pharmaceutical research : IJPR · 2016Article
- Phenolic Derivatives of Artemisia Spicigera C. Koch Growing in Iran.Iranian journal of pharmaceutical research : IJPR · 2015Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The formation of hemozoin (malaria pigment) has been proposed as an ideal drug target for antimalarial screening programs. In this study, we used an improved, cost-effective and high-throughput spectrophotometric assay to screen plant extracts for finding novel antimalarial plant sources. Fifteen extracts with different polarity from three Iranian Artemisia species, A. ciniformis, A. biennis and A. turanica, were assessed for their antimalarial activity by in-vitro β-hematin formation assay. The most potent effect was observed in dichloromethane (DCM) extract of A. ciniformis with IC50 and IC90 values of 0.92 ± 0.01 and 1.29 ± 0.02 mg/mL, respectively. Ethyl acetate (EtOAC) extracts of A. biennis and A. turanica also showed significant antimalarial activities with IC50 values of 1.11 ± 0.02 and 1.35 ± 0.08 mg/mL and IC90 values of 1.22 ± 0.04 and 2.81 ± 0.21 mg/mL, respectively. Based on these results, it is possible to conclude that the components with strong antimalarial activity have been concentrated in the medium-polar extracts.
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25901169PMC4403078W1893829408What OpenQuestion holds
Registered trials
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