Evidence map›Paper›PMID 25901045›Full record

ArticleCirculation. Cardiovascular quality and outcomes2015

Recognition of incident diabetes mellitus during an acute myocardial infarction.

Suzanne V Arnold, Joshua M Stolker, Kasia J Lipska, Philip G Jones, John A Spertus, Darren K McGuire, Silvio E Inzucchi, Abhinav Goyal, Thomas M Maddox, Marcus Lind and 3 more

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Cardiovascular quality and outcomes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
  2. Article
  3. Quality of Diabetes Care in the USA.Current cardiology reports · 2021
    Review
  4. Observational
  5. Article
  6. Article
  7. Article
  8. Hemoglobin ACardiovascular diabetology · 2017
    Article
  9. HbAJournal of diabetes and metabolic disorders · 2017
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Suzanne V ArnoldFrom the Saint Luke's Mid America Heart Institute, Kansas City, MO (S.V.A., P.G.J., J.A.S., M.K.); University of Missouri-Kansas City (S.V.A., J.A.S., M.K.); Saint Louis University, MO (J.M.S.); Yale University School of Medicine, New Haven, CT (K.J.L., S.E.I.); University of Texas Southwestern Medical Center, Dallas (D.K.M.); Emory School of Medicine, Atlanta, GA (A.G.); VA Eastern Colorado Health Care System, Denver (T.M.M.); University of Gothenburg, Gothenburg, Sweden (M.L.); and Cleveland Clinic Foundation, OH (D.G.). suz.v.arnold@gmail.com.
Joshua M StolkerFrom the Saint Luke's Mid America Heart Institute, Kansas City, MO (S.V.A., P.G.J., J.A.S., M.K.); University of Missouri-Kansas City (S.V.A., J.A.S., M.K.); Saint Louis University, MO (J.M.S.); Yale University School of Medicine, New Haven, CT (K.J.L., S.E.I.); University of Texas Southwestern Medical Center, Dallas (D.K.M.); Emory School of Medicine, Atlanta, GA (A.G.); VA Eastern Colorado Health Care System, Denver (T.M.M.); University of Gothenburg, Gothenburg, Sweden (M.L.); and Cleveland Clinic Foundation, OH (D.G.).
Kasia J LipskaFrom the Saint Luke's Mid America Heart Institute, Kansas City, MO (S.V.A., P.G.J., J.A.S., M.K.); University of Missouri-Kansas City (S.V.A., J.A.S., M.K.); Saint Louis University, MO (J.M.S.); Yale University School of Medicine, New Haven, CT (K.J.L., S.E.I.); University of Texas Southwestern Medical Center, Dallas (D.K.M.); Emory School of Medicine, Atlanta, GA (A.G.); VA Eastern Colorado Health Care System, Denver (T.M.M.); University of Gothenburg, Gothenburg, Sweden (M.L.); and Cleveland Clinic Foundation, OH (D.G.).
Philip G JonesFrom the Saint Luke's Mid America Heart Institute, Kansas City, MO (S.V.A., P.G.J., J.A.S., M.K.); University of Missouri-Kansas City (S.V.A., J.A.S., M.K.); Saint Louis University, MO (J.M.S.); Yale University School of Medicine, New Haven, CT (K.J.L., S.E.I.); University of Texas Southwestern Medical Center, Dallas (D.K.M.); Emory School of Medicine, Atlanta, GA (A.G.); VA Eastern Colorado Health Care System, Denver (T.M.M.); University of Gothenburg, Gothenburg, Sweden (M.L.); and Cleveland Clinic Foundation, OH (D.G.).
John A SpertusFrom the Saint Luke's Mid America Heart Institute, Kansas City, MO (S.V.A., P.G.J., J.A.S., M.K.); University of Missouri-Kansas City (S.V.A., J.A.S., M.K.); Saint Louis University, MO (J.M.S.); Yale University School of Medicine, New Haven, CT (K.J.L., S.E.I.); University of Texas Southwestern Medical Center, Dallas (D.K.M.); Emory School of Medicine, Atlanta, GA (A.G.); VA Eastern Colorado Health Care System, Denver (T.M.M.); University of Gothenburg, Gothenburg, Sweden (M.L.); and Cleveland Clinic Foundation, OH (D.G.).
Darren K McGuireFrom the Saint Luke's Mid America Heart Institute, Kansas City, MO (S.V.A., P.G.J., J.A.S., M.K.); University of Missouri-Kansas City (S.V.A., J.A.S., M.K.); Saint Louis University, MO (J.M.S.); Yale University School of Medicine, New Haven, CT (K.J.L., S.E.I.); University of Texas Southwestern Medical Center, Dallas (D.K.M.); Emory School of Medicine, Atlanta, GA (A.G.); VA Eastern Colorado Health Care System, Denver (T.M.M.); University of Gothenburg, Gothenburg, Sweden (M.L.); and Cleveland Clinic Foundation, OH (D.G.).
Silvio E InzucchiFrom the Saint Luke's Mid America Heart Institute, Kansas City, MO (S.V.A., P.G.J., J.A.S., M.K.); University of Missouri-Kansas City (S.V.A., J.A.S., M.K.); Saint Louis University, MO (J.M.S.); Yale University School of Medicine, New Haven, CT (K.J.L., S.E.I.); University of Texas Southwestern Medical Center, Dallas (D.K.M.); Emory School of Medicine, Atlanta, GA (A.G.); VA Eastern Colorado Health Care System, Denver (T.M.M.); University of Gothenburg, Gothenburg, Sweden (M.L.); and Cleveland Clinic Foundation, OH (D.G.).
Abhinav GoyalFrom the Saint Luke's Mid America Heart Institute, Kansas City, MO (S.V.A., P.G.J., J.A.S., M.K.); University of Missouri-Kansas City (S.V.A., J.A.S., M.K.); Saint Louis University, MO (J.M.S.); Yale University School of Medicine, New Haven, CT (K.J.L., S.E.I.); University of Texas Southwestern Medical Center, Dallas (D.K.M.); Emory School of Medicine, Atlanta, GA (A.G.); VA Eastern Colorado Health Care System, Denver (T.M.M.); University of Gothenburg, Gothenburg, Sweden (M.L.); and Cleveland Clinic Foundation, OH (D.G.).
Thomas M MaddoxFrom the Saint Luke's Mid America Heart Institute, Kansas City, MO (S.V.A., P.G.J., J.A.S., M.K.); University of Missouri-Kansas City (S.V.A., J.A.S., M.K.); Saint Louis University, MO (J.M.S.); Yale University School of Medicine, New Haven, CT (K.J.L., S.E.I.); University of Texas Southwestern Medical Center, Dallas (D.K.M.); Emory School of Medicine, Atlanta, GA (A.G.); VA Eastern Colorado Health Care System, Denver (T.M.M.); University of Gothenburg, Gothenburg, Sweden (M.L.); and Cleveland Clinic Foundation, OH (D.G.).
Marcus LindFrom the Saint Luke's Mid America Heart Institute, Kansas City, MO (S.V.A., P.G.J., J.A.S., M.K.); University of Missouri-Kansas City (S.V.A., J.A.S., M.K.); Saint Louis University, MO (J.M.S.); Yale University School of Medicine, New Haven, CT (K.J.L., S.E.I.); University of Texas Southwestern Medical Center, Dallas (D.K.M.); Emory School of Medicine, Atlanta, GA (A.G.); VA Eastern Colorado Health Care System, Denver (T.M.M.); University of Gothenburg, Gothenburg, Sweden (M.L.); and Cleveland Clinic Foundation, OH (D.G.).
Divya GumberFrom the Saint Luke's Mid America Heart Institute, Kansas City, MO (S.V.A., P.G.J., J.A.S., M.K.); University of Missouri-Kansas City (S.V.A., J.A.S., M.K.); Saint Louis University, MO (J.M.S.); Yale University School of Medicine, New Haven, CT (K.J.L., S.E.I.); University of Texas Southwestern Medical Center, Dallas (D.K.M.); Emory School of Medicine, Atlanta, GA (A.G.); VA Eastern Colorado Health Care System, Denver (T.M.M.); University of Gothenburg, Gothenburg, Sweden (M.L.); and Cleveland Clinic Foundation, OH (D.G.).
Supriya ShoreFrom the Saint Luke's Mid America Heart Institute, Kansas City, MO (S.V.A., P.G.J., J.A.S., M.K.); University of Missouri-Kansas City (S.V.A., J.A.S., M.K.); Saint Louis University, MO (J.M.S.); Yale University School of Medicine, New Haven, CT (K.J.L., S.E.I.); University of Texas Southwestern Medical Center, Dallas (D.K.M.); Emory School of Medicine, Atlanta, GA (A.G.); VA Eastern Colorado Health Care System, Denver (T.M.M.); University of Gothenburg, Gothenburg, Sweden (M.L.); and Cleveland Clinic Foundation, OH (D.G.).
Mikhail KosiborodFrom the Saint Luke's Mid America Heart Institute, Kansas City, MO (S.V.A., P.G.J., J.A.S., M.K.); University of Missouri-Kansas City (S.V.A., J.A.S., M.K.); Saint Louis University, MO (J.M.S.); Yale University School of Medicine, New Haven, CT (K.J.L., S.E.I.); University of Texas Southwestern Medical Center, Dallas (D.K.M.); Emory School of Medicine, Atlanta, GA (A.G.); VA Eastern Colorado Health Care System, Denver (T.M.M.); University of Gothenburg, Gothenburg, Sweden (M.L.); and Cleveland Clinic Foundation, OH (D.G.).
University of Gothenburg · SEThe University of Texas Southwestern Medical Center · USEmory University · USSaint Louis University · USUniversity of Missouri–Kansas City · USYale University · US

Funding

SCCOR in Cardiac Dysfunction and DiseaseP50HL077113 · NHLBI · WASHINGTON UNIVERSITY · PI KELLY, DANIEL PATRICK · 2005 to 2009
$13.4M
Predicting Severe Hypoglycemia among Older Adults with DiabetesK23AG048359 · NIA · YALE UNIVERSITY · PI LIPSKA, KASIA JOANNA · 2014 to 2018
$778k
NHLBI NIH HHS 50HL077113-01NHLBI NIH HHS P50 HL077113NIA NIH HHS K23 AG048359
6 · The paper itself

Abstract

backgroundDiabetes mellitus (DM) is common in patients hospitalized with an acute myocardial infarction (AMI), representing in some cases the first opportunity to recognize and treat DM. We report the incidence of new DM and its recognition among patients with AMI. METHODS AND

resultsPatients in a 24-site US AMI registry (2005-08) had glycosylated hemoglobin assessed at a core laboratory, with results blinded to clinicians and local clinical measurements left to the discretion of the treating providers. Among 2854 AMI patients without known DM on admission, 287 patients (10%) met criteria for previously unknown DM, defined by a core laboratory glycosylated hemoglobin of ≥6.5%. Among these, 186 (65%) were unrecognized by treating clinicians, receiving neither DM education, glucose-lowering medications at discharge, nor documentation of DM in the chart (median glycosylated hemoglobin of unrecognized patients, 6.7%; range, 6.5-12.3%). Six months after discharge, only 5% of those not recognized as having DM during hospitalization had been initiated on glucose-lowering medications versus 66% of those recognized (P<0.001).

conclusionsUnderlying DM that has not been previously diagnosed is common among AMI patients, affecting 1 in 10 patients, yet is recognized by the care team only one third of the time. Given its frequency and therapeutic implications, including but extending beyond the initiation of glucose-lowering treatment, consideration should be given to screening all AMI patients for DM during hospitalization. Inexpensive, ubiquitous, and endorsed as an acceptable screen for DM, glycosylated hemoglobin testing should be considered for this purpose.

Indexed as

RegistriesAgedDiabetes MellitusFemaleGlycated HemoglobinHumansHypoglycemic AgentsMaleMass ScreeningMiddle AgedMyocardial InfarctionGlycated Hemoglobinhemoglobin A1c protein, humanHypoglycemic Agentsdiabetes mellitushemoglobin A, glycosylatedmyocardial infarctionquality of health care

Identifiers

PMID25901045
PMCPMC4439264
OpenAlexW2038076245

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.