ReviewThe Journal of endocrinology2015
60 YEARS OF NEUROENDOCRINOLOGY: The hypothalamo-pituitary-gonadal axis.
Review in The Journal of endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
120 citing papers in PubMed, 2 syntheses or guidelines pooled it, 255 citations in OpenAlex.
- Contemplative-based interventions for premenstrual syndrome: a systematic review of psychobiological outcomes.Frontiers in psychology · 2026Pooled it
- Translational interdisciplinary research on human chorionic gonadotropin's enhancement of neuroendocrine crosstalk: a novel medical hypothesis for systemic adjunctive treatment of psychiatric disorders.Frontiers in psychiatry · 2025Pooled it
- Article
- Seasonal fluctuations in the hypothalamic irisin and its correlation with the hypothalamic-pituitary-gonadal -axis activity in male rhesus monkeys (Macaca mulatta).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- Acute Endocrine and Lipid Responses to Extreme Ultramarathon Running Across 100, 308, and 622 km Events.Life (Basel, Switzerland) · 2026Article
- Disruption of gonadal steroidogenesis and reproductive function in Gambusia affinis after chronic exposure to environmentally relevant and sublethal concentrations of carbamazepine.Fish physiology and biochemistry · 2026Article
- Understanding the Role of Hypothalamic-Pituitary-Gonadal Axis in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis.Biomedicines · 2026Review
- Systematic proteomic analysis of neuroimaging metrics identifies therapeutic targets for pituitary neuroendocrine.NPJ systems biology and applications · 2026Article
- Health consequences of anabolic steroids: a sexual-medicine perspective.International journal of impotence research · 2026Review
- Unravelling Twin Births in German Holstein Cows: Phenotypic Associations, Genetic Analysis and Potential Underlying Genes and Hormones.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026Article
- Profile of gonadotropin secretion in male and female rats determined in the tail-tip blood by ultrasensitive ELISA.Journal of neuroendocrinology · 2026Article
- Appetitive maternal behavior in mice is resistant to perinatal chronic variable stress and perinatal chronic corticosterone treatment.Hormones and behavior · 2026Article
- Serum and serum-derived extracellular vesicle microRNA signatures linked to neurodevelopmental processes in central precocious puberty.Frontiers in endocrinology · 2026Article
- Analysis of circular RNA (circRNA) characteristics and identification of key circRNAs in the hypothalamus during sexual maturation in female goats.Animal bioscience · 2025Article
- Unraveling a Subgroup of Men With Unexplained Male Infertility-Men With Normogonadotropic Nonobstructive Azoospermia.The Journal of clinical endocrinology and metabolism · 2025Article
- Disruption of ovarian function and induction of apoptosis in female mice by Brefeldin A: Mechanistic insights into reproductive toxicity.Animal models and experimental medicine · 2025Article
- Article
- The microbiota extends the reproductive lifespan of mice by safeguarding the ovarian reserve.Cell host & microbe · 2025Article
- Review
- Functions of RhoA in the female reproductive system.Reproductive and developmental medicine · 2025Review
60 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
This review provides an outline of how our understanding of the neuroendocrine control of the hypothalamo-pituitary-gonadal axis has evolved since the publication of Geoffrey Harris' renowned monograph in 1955. Particular attention is directed to the neurobiology underlying pulsatile GnRH release from the hypothalamus, the neuroendocrine control of ovarian cycles, puberty and seasonality of gonadal function, and to ideas that have emerged as a result of examining the relationship between growth and the reproductive axis. The review closes with i) a brief discussion of how knowledge gained as a result of pursuing the early hypotheses of Harris has led to major clinical and therapeutic applications, and ii) a personal glimpse into the future of research in this fascinating area of biology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.