ReviewCirculation. Cardiovascular genetics2015
Integrated metabolomics and genomics: systems approaches to biomarkers and mechanisms of cardiovascular disease.
Review in Circulation. Cardiovascular genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed.
- Prognostic Implications of Long-Chain Acylcarnitines in Heart Failure and Reversibility With Mechanical Circulatory Support.Journal of the American College of Cardiology · 2016Trial
- Overview of molecular mechanisms underlying stress responses; signaling pathways and secondary metabolite synthesis in plants.Plant molecular biology · 2026Review
- Review
- Pathological mechanisms and research progress of multilevel intervention therapy for coronary heart disease.Frontiers in immunology · 2026Review
- Associations of wearable photobiomodulation device use with mitochondrial bioenergetics and fatigue in athletes and individuals with chronic fatigue.Frontiers in sports and active living · 2026Article
- Metabolites and coronary heart disease: A two sample Mendelian randomization.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Advancements in Biomarkers for Early Detection and Risk Stratification of Cardiovascular Diseases-A Literature Review.Health science reports · 2025Article
- From Data to Cure: A Comprehensive Exploration of Multi-omics Data Analysis for Targeted Therapies.Molecular biotechnology · 2025Review
- Metabolome Alterations Associated with Three-Month Sitting-Time Reduction Among Sedentary Postmenopausal Latinas with Cardiometabolic Disease Risk.Metabolites · 2025Article
- Metabolic and inflammatory axes of insulin resistance in normoglycemic adults with high HIV burden.PLOS global public health · 2025Article
- Genes to therapy: a comprehensive literature review of whole-exome sequencing in neurology and neurosurgery.European journal of medical research · 2024Review
- Sitting Interruption Modalities during Prolonged Sitting Acutely Improve Postprandial Metabolome in a Crossover Pilot Trial among Postmenopausal Women.Metabolites · 2024Article
- Adverse cardiovascular and metabolic perturbations among older women: 'fat-craving' hearts.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Article
- Systemic Metabolomics in a Framework of Genetics and Lifestyle in Age-Related Macular Degeneration.Metabolites · 2023Article
- Precision medicine for long QT syndrome: patient-specific iPSCs take the lead.Expert reviews in molecular medicine · 2023Review
- Data Processing and Analysis in Mass Spectrometry-Based Metabolomics.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Metabolome-Wide Association Study of Cord Blood Metabolites With Blood Pressure in Childhood and Adolescence.Hypertension (Dallas, Tex. : 1979) · 2022Article
- On the Verge of Precision Medicine in Diabetes.Drugs · 2022Review
- Bibliometric and Visual Analysis on Metabolomics in Coronary Artery Disease Research.Frontiers in cardiovascular medicine · 2022Article
- Integrative Analysis of Multi-Omics and Genetic Approaches-A New Level in Atherosclerotic Cardiovascular Risk Prediction.Biomolecules · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The genetic architecture underlying the heritability of cardiovascular disease is incompletely understood. Metabolomics is an emerging technology platform that has shown early success in identifying biomarkers and mechanisms of common chronic diseases. Integration of metabolomics, genetics, and other omics platforms in a systems biology approach holds potential for elucidating novel genetic markers and mechanisms for cardiovascular disease. We review important studies that have used metabolomic profiling in cardiometabolic diseases, approaches for integrating metabolomics with genetics and other molecular profiling platforms, and key studies showing the potential for such studies in deciphering cardiovascular disease genetics, biomarkers, and mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.