Evidence map›Paper›PMID 25900974›Full record

ArticleMolecular and cellular biology2015

TPC1 Knockout Knocks Out TPC1.

Robert Hooper, Dev Churamani, Sean M Davidson, Yaping Lin-Moshier, Timothy F Walseth, Sandip Patel, Jonathan S Marchant

Abstract readLetterComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Two-pore channels and disease.Biochimica et biophysica acta. Molecular cell research · 2018
    Review
  2. Article
  3. Two-Pore Channels: Lessons from Mutant Mouse Models.Messenger (Los Angeles, Calif. : Print) · 2015
    Article
  4. Reply to "TPC1 Knockout Knocks Out TPC1".Molecular and cellular biology · 2015
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Robert HooperDepartment of Cell and Developmental Biology, University College London, London, United Kingdom.
Dev ChuramaniDepartment of Cell and Developmental Biology, University College London, London, United Kingdom.
Sean M DavidsonDepartment of Medicine, Hatter Cardiovascular Institute, University College London, London, United Kingdom.
Yaping Lin-MoshierDepartment of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Timothy F WalsethDepartment of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Sandip PatelDepartment of Cell and Developmental Biology, University College London, London, United Kingdom.
Jonathan S MarchantDepartment of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, USA march029@umn.edu.

Funding

Functional architecture of IP3-evoked local Ca2+ signalsR01GM088790 · NIGMS · UNIVERSITY OF MINNESOTA · PI MARCHANT, JONATHAN S, SLAMA, JAMES T · 2009 to 2025
$4.7M
Biotechnology and Biological Sciences Research Council BB/G013721/1NIGMS NIH HHS R01 GM088790
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCalcium ChannelsLysosomesCalcium Channels

Identifiers

PMID25900974
PMCPMC4405651

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.