Observational studyGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2016
Spectral-domain optical coherence tomography reveals prelaminar membranes in optic nerve head pallor in eyes with retinitis pigmentosa.
Observational study in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 21 citations in OpenAlex.
- An Optical Coherence Tomography-Based Measure as an Independent Estimate of Retinal Function in Retinitis Pigmentosa.Diagnostics (Basel, Switzerland) · 2023Article
- Ocular abnormalities in a large patient cohort with retinitis pigmentosa in Western China.BMC ophthalmology · 2021Article
- Characterization of Inner Retinal Hyperreflective Alterations in Early Cognitive Impairment on Adaptive Optics Scanning Laser Ophthalmoscopy.Investigative ophthalmology & visual science · 2019Article
- Electronic retinal implant surgery.Eye (London, England) · 2017Article
- Whole-body positional manipulators for ocular imaging of anaesthetised mice and rats: a do-it-yourself guide.BMJ open ophthalmology · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo determine the relationship between prelaminar structural changes of the optic nerve head (ONH) and optic nerve waxy pallor in retinitis pigmentosa (RP) using spectral-domain optical coherence tomography (SD-OCT) and fundus photography.
methodsAn observational cross-sectional case control study of patients with RP with and without ONH waxy pallor and controls. Subjects underwent clinical examination, fundus photography, and SD-OCT raster imaging of the ONH. Four independent specialists reviewed the images in a masked fashion.
resultsFifty-five eyes of 31 subjects with RP and 28 eyes of 14 controls were included. Optic nerve head waxy pallor was seen in 29 RP eyes (52.7 %) and none in controls. SD-OCT showed a hyper-reflective structure suggestive of a glial membrane-like structure on the surface of ONH in 16 of RP eyes (55.1 %). In the RP group, there was a significant positive correlation between the ONH pallor and the presence of a prelaminar structure (p = 0.006).
conclusionsThere is a presence of glial membrane-like structures on the optic nerve head surface in eyes with RP compared to healthy eyes. As the presence of glial membranes correlated with the presence of ONH waxy pallor, in such cases these membranes might be responsible for ONH waxy pallor.
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