Evidence map›Paper›PMID 25900731›Full record

GuidelineThyroid : official journal of the American Thyroid Association2015

Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer.

Gary L Francis, Steven G Waguespack, Andrew J Bauer, Peter Angelos, Salvatore Benvenga, Janete M Cerutti, Catherine A Dinauer, Jill Hamilton, Ian D Hay, Markus Luster and 5 more

Open access · hybridAbstract readPractice GuidelineReview
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Thyroid : official journal of the American Thyroid Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 488 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
488citing papers in PubMed, 4 pooled it
58.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

488 citing papers in PubMed, 4 syntheses or guidelines pooled it, 1,202 citations in OpenAlex.

  1. Predictors of thyroid cancer in paediatric patients with thyroid nodules: A systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Pooled it
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  20. Evolving trends in pediatric thyroid nodules and cancer management.Annals of pediatric endocrinology & metabolism · 2026
    Article

428 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 13 institutions in 7 countries.

Gary L Francis1 Division of Pediatric Endocrinology, Virginia Commonwealth University , Children's Hospital of Richmond, Richmond, Virginia.
Steven G Waguespack2 Department of Endocrine Neoplasia and Hormonal Disorders and Department of Pediatrics-Patient Care, Children's Cancer Hospital, University of Texas MD Anderson Cancer Center , Houston, Texas.
Andrew J Bauer3 Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia , Philadelphia, Pennsylvania.
Peter Angelos5 Section of General Surgery and Surgical Oncology, Department of Surgery, University of Chicago Medicine , Chicago, Illinois.
Salvatore Benvenga6 University of Messina , Interdepartmental Program on Clinical & Molecular Endocrinology, and Women's Endocrine Health, A.O.U. Policlinico Universitario G. Martino, Messina, Italy .
Janete M Cerutti7 Department of Morphology and Genetics. Division of Genetics, Federal University of São Paulo , São Paulo, Brazil .
Catherine A Dinauer8 Department of Surgery, Division of Pediatric Surgery, Department of Pediatrics, Division of Pediatric Endocrinology, Yale University School of Medicine , New Haven, Connecticut.
Jill Hamilton9 Division of Endocrinology, University of Toronto , Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada .
Ian D Hay10 Division of Endocrinology, Mayo Clinic and College of Medicine , Rochester, Minnesota.
Markus Luster11 University of Marburg , Marburg, Germany .
Marguerite T Parisi13 Departments of Radiology and Pediatrics, University of Washington School of Medicine and Seattle Children's Hospital , Department of Radiology, Seattle, Washington.
Marianna Rachmiel14 Pediatric Division, Assaf Haroffeh Medical Center , Zerifin, Israel .
Geoffrey B Thompson16 Department of Surgery, Division of Subspecialty GS (General Surgery), Mayo Clinic , Rochester, Minnesota.
Shunichi Yamashita17 Atomic Bomb Disease Institute, Nagasaki University , Nagasaki, Japan .
American Thyroid Association Guidelines Task Force
Mayo Clinic · USChildren's Hospital of Philadelphia · USMorpho (United States) · USNagasaki University · JPPhilipps University of Marburg · DESeattle Children's Hospital · USTel Aviv University · ILThe University of Texas MD Anderson Cancer Center · USUniversity of Chicago · USUniversity of Messina · ITUniversity of Toronto · CAVirginia Commonwealth University · USYale University · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
6 · The paper itself

Abstract

backgroundPrevious guidelines for the management of thyroid nodules and cancers were geared toward adults. Compared with thyroid neoplasms in adults, however, those in the pediatric population exhibit differences in pathophysiology, clinical presentation, and long-term outcomes. Furthermore, therapy that may be recommended for an adult may not be appropriate for a child who is at low risk for death but at higher risk for long-term harm from overly aggressive treatment. For these reasons, unique guidelines for children and adolescents with thyroid tumors are needed.

methodsA task force commissioned by the American Thyroid Association (ATA) developed a series of clinically relevant questions pertaining to the management of children with thyroid nodules and differentiated thyroid cancer (DTC). Using an extensive literature search, primarily focused on studies that included subjects ≤18 years of age, the task force identified and reviewed relevant articles through April 2014. Recommendations were made based upon scientific evidence and expert opinion and were graded using a modified schema from the United States Preventive Services Task Force.

resultsThese inaugural guidelines provide recommendations for the evaluation and management of thyroid nodules in children and adolescents, including the role and interpretation of ultrasound, fine-needle aspiration cytology, and the management of benign nodules. Recommendations for the evaluation, treatment, and follow-up of children and adolescents with DTC are outlined and include preoperative staging, surgical management, postoperative staging, the role of radioactive iodine therapy, and goals for thyrotropin suppression. Management algorithms are proposed and separate recommendations for papillary and follicular thyroid cancers are provided.

conclusionsIn response to our charge as an independent task force appointed by the ATA, we developed recommendations based on scientific evidence and expert opinion for the management of thyroid nodules and DTC in children and adolescents. In our opinion, these represent the current optimal care for children and adolescents with these conditions.

Indexed as

Adenocarcinoma, FollicularAdenoma, OxyphilicAdolescentBiopsy, Fine-NeedleCarcinomaCarcinoma, PapillaryChildDisease ManagementHumansSocieties, MedicalThyroid Cancer, PapillaryThyroid GlandThyroid NeoplasmsThyroid NoduleUltrasonographyUnited States

Identifiers

PMID25900731
PMCPMC4854274
OpenAlexW2314815360

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.