Evidence map›Paper›PMID 25900577›Full record

ArticlePediatric blood & cancer2015

Successful hematopoietic cell transplantation in a patient with X-linked agammaglobulinemia and acute myeloid leukemia.

Rolla F Abu-Arja, Leah R Chernin, Ghada Abusin, Jeffery Auletta, Linda Cabral, Rachel Egler, Hans D Ochs, Troy R Torgerson, Jesus Lopez-Guisa, Robert W Hostoffer and 2 more

Open access · greenAbstract readCase Reports
In one paragraph

Article in Pediatric blood & cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Revisiting X-linked agammaglobulinemia.Journal of human immunity · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. [Structure and function of B-cell linker and its role in the development of B cell-related diseases].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019
    Article
  13. A NovelFrontiers in immunology · 2019
    Article
  14. Article
  15. X-linked Agammaglobulinemia.Indian journal of pediatrics · 2016
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Rolla F Abu-ArjaPediatric Blood and Marrow Transplant Program, Nationwide Children's Hospital, Columbus, Ohio.
Leah R CherninAllergy/Immunology Associates, Inc., Case Western Reserve University, Cleveland, Ohio.
Ghada AbusinPediatric Bone Marrow Transplant Program, University of Iowa Children's Hospital, Iowa City, Iowa.
Jeffery AulettaPediatric Blood and Marrow Transplant Program, Nationwide Children's Hospital, Columbus, Ohio.
Linda CabralPediatric Bone Marrow Transplant, Rainbow Babies and Children's Hospital, Case Medical Center, Cleveland, Ohio.
Rachel EglerPediatric Bone Marrow Transplant, Rainbow Babies and Children's Hospital, Case Medical Center, Cleveland, Ohio.
Hans D OchsUniversity of Washington and Seattle Children's Research Institute, Seattle, Washington.
Troy R Torgerson
Jesus Lopez-GuisaUniversity of Washington and Seattle Children's Research Institute, Seattle, Washington.
Robert W HostofferAllergy/Immunology Associates, Inc., Case Western Reserve University, Cleveland, Ohio.
Haig TcheurekdjianAllergy/Immunology Associates, Inc., Case Western Reserve University, Cleveland, Ohio.
Kenneth R CookePediatric Blood and Marrow Transplant, Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, Maryland.
Boston Children's Hospital · USCase Western Reserve University · USNationwide Children's Hospital · USSeattle Children's Hospital · USSidney Kimmel Cancer Center · USUniversity of Washington · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6M
NCI NIH HHS P30 CA006973
6 · The paper itself

Abstract

X-linked agammaglobulinemia (XLA) is a primary immunodeficiency characterized by marked reduction in all classes of serum immunoglobulins and the near absence of mature CD19(+) B-cells. Although malignancy has been observed in patients with XLA, we present the first reported case of acute myeloid leukemia (AML) in a patient with XLA. We also demonstrate the complete correction of the XLA phenotype following allogeneic hematopoietic cell transplantation for treatment of the patient's leukemia.

Indexed as

Peripheral Blood Stem Cell TransplantationAgammaglobulinemiaAllograftsAntibodies, BacterialAntigens, CD19Antineoplastic Combined Chemotherapy ProtocolsB-Lymphocyte SubsetsChild, PreschoolCombined Modality TherapyGenetic Diseases, X-LinkedHumansImmunoglobulins, IntravenousLeukemia, Myeloid, AcuteLymphocyte CountMalePneumococcal VaccinesAntibodies, BacterialAntigens, CD19Immunoglobulins, IntravenousPneumococcal Vaccinesacute myeloid leukemiastem cell transplantationX-linked agammaglobulinemia

Identifiers

PMID25900577
PMCPMC4876715
OpenAlexW1923706937

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.