ArticleThe Journal of nervous and mental disease2015
Ten-Year Outcomes of First-Episode Psychoses in the MRC ÆSOP-10 Study.
Article in The Journal of nervous and mental disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 4 syntheses or guidelines pooled it, 109 citations in OpenAlex.
- Effectiveness of psychological interventions for carers of patients with severe mental illness (SMI): a systematic review.BMJ open · 2024Pooled it
- Schizophrenia outcomes in the 21st century: A systematic review.Brain and behavior · 2021Pooled it
- Specialised early intervention teams (extended time) for recent-onset psychosis.The Cochrane database of systematic reviews · 2020Pooled it
- Specialised early intervention teams for recent-onset psychosis.The Cochrane database of systematic reviews · 2020Pooled it
- Predictors and moderators of burden of care and emotional distress in first-episode psychosis caregivers: results from the GET UP pragmatic cluster randomised controlled trial.Epidemiology and psychiatric sciences · 2019Trial
- Racial-Ethnic Disparities in First-Episode Psychosis Treatment Outcomes From the RAISE-ETP Study.Psychiatric services (Washington, D.C.) · 2018Trial
- Predictors of long term use of psychiatric services of patients with recent-onset schizophrenia: 12 years follow-up.BMC psychiatry · 2017Trial
- Five years of specialised early intervention versus two years of specialised early intervention followed by three years of standard treatment for patients with a first episode psychosis: randomised, superiority, parallel group trial in Denmark (OPUS II).BMJ (Clinical research ed.) · 2017Trial
- Translating Evidence for Early Intervention in Psychosis (TRANSLATE): Protocol for Evaluating the Implementation of Early Intervention in Psychosis in Low and Lower-Middle Income Countries (LMICs).Early intervention in psychiatry · 2026Observational
- The Association of Antipsychotic Treatment and Side Effects With Societal Recovery and Happiness: A Naturalistic Cohort Study of People in Long-term Care for a Psychotic Disorder.Schizophrenia bulletin · 2026Article
- The impact of symptoms and illness insight on treatment adherence in first-episode psychosis: a one-year follow-up study using therapeutic drug monitoring.BMC psychiatry · 2026Article
- Adaptation of a brief intervention to support engagement in early psychosis services: a service user-informed psychotherapy modification and study protocol.Frontiers in psychology · 2026Article
- Longitudinal recovery and self-efficacy in first-episode schizophrenia: insights from a 10-year follow-up study.Frontiers in psychiatry · 2025Article
- Spatial metabolomics in mental disorders and traditional Chinese medicine: a review.Frontiers in pharmacology · 2025Review
- Development and initial evaluation of a clinical prediction model for risk of treatment resistance in first-episode psychosis: Schizophrenia Prediction of Resistance to Treatment (SPIRIT).The British journal of psychiatry : the journal of mental science · 2024Article
- A Thematic Analysis Investigating the Inaugural Psychosis REACH Family Ambassador Peer Training Program.Neuropsychiatric disease and treatment · 2024Article
- User-Centered Development of Bolster, an mHealth Intervention for Early Psychosis Caregivers: Needs Assessment, Prototyping, and Field Trial.JMIR mental health · 2023Article
- The Lived Experiences of Family Members and Carers of People with Psychosis: A Bottom-Up Review Co-Written by Experts by Experience and Academics.Psychopathology · 2023Review
- Neuroimaging in schizophrenia: an overview of findings and their implications for synaptic changes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Effectiveness of Clozapine on Employment Outcomes in Treatment-Resistant Schizophrenia: A Retrospective Bidirectional Mirror-Image Study.Neuropsychiatric disease and treatment · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 3 institutions in 5 countries.
Funding
Abstract
It has long been held that schizophrenia and other psychotic disorders have a predominately poor course and outcome. We have synthesized information on mortality, clinical and social outcomes from the ÆSOP-10 multicenter study, a 10-year follow-up of a large epidemiologically characterized cohort of 557 people with first-episode psychosis. Symptomatic remission and recovery were more common than previously believed. Distinguishing between symptom and social recovery is important given the disparity between these; even when symptomatic recovery occurs social inclusion may remain elusive. Multiple factors were associated with an increased risk of mortality, but unnatural death was reduced by 90% when there was full family involvement at first contact compared with those without family involvement. These results suggest that researchers, clinicians and those affected by psychosis should countenance a much more optimistic view of symptomatic outcome than was assumed when these conditions were first described.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.