Evidence map›Paper›PMID 25900255›Full record

ArticleAnnals of epidemiology2015

Construct validation of the dietary inflammatory index among postmenopausal women.

Fred K Tabung, Susan E Steck, Jiajia Zhang, Yunsheng Ma, Angela D Liese, Ilir Agalliu, Melanie Hingle, Lifang Hou, Thomas G Hurley, Li Jiao and 8 more

Registry-linked trialAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05618626 (Cardiovascular Diseases), which is not on this map. Cited by 246 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
246citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05618626 narecruitingnot on this mapstarted 2021, after this paper: background citation

Cardiovascular Diseases (CVD) and Nonalcoholic Fatty Liver Diseases (NAFLD) Among Gallstone and Cholecystectomy Patients and the Impact of a Novel Diet and Muscle Training Program

TypeinterventionalSponsorPontificia Universidad Catolica de ChileRan2021 to 2025Enrolled300ConditionsNon-Alcoholic Fatty Liver Disease, Gallstone DiseaseArmsPhysical exercise and dietary intervention for NAFLD
3 · Its place in the literature

Who cites it

246 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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186 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Fred K TabungSouth Carolina Statewide Cancer Prevention and Control Program, University of South Carolina, Columbia; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia.
Susan E SteckSouth Carolina Statewide Cancer Prevention and Control Program, University of South Carolina, Columbia; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia; Center for Research in Nutrition and Health Disparities, University of South Carolina, Columbia. Electronic address: ssteck@sc.edu.
Jiajia ZhangDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia.
Yunsheng MaDivision of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Boston.
Angela D LieseDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia; Center for Research in Nutrition and Health Disparities, University of South Carolina, Columbia.
Ilir AgalliuDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY.
Melanie HingleDepartment of Nutritional Sciences, College of Agriculture and Life Sciences, The University of Arizona, Tucson.
Lifang HouDepartment of Preventive Medicine and the Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Thomas G HurleySouth Carolina Statewide Cancer Prevention and Control Program, University of South Carolina, Columbia.
Li JiaoDepartment of Medicine, Baylor College of Medicine, Houston, TX.
Lisa W MartinCardiology Division, School of Medicine and Health Sciences, George Washington University, Washington, DC.
Amy E MillenDepartment of Epidemiology and Environmental Health, University at Buffalo, The State University of New York, Buffalo.
Hannah L ParkDepartment of Epidemiology, School of Medicine, University of California at Irvine, Irvine.
Milagros C RosalDivision of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Boston.
James M ShikanyDivision of Preventive Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham.
Nitin ShivappaSouth Carolina Statewide Cancer Prevention and Control Program, University of South Carolina, Columbia; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia.
Judith K OckeneDivision of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Boston.
James R HebertSouth Carolina Statewide Cancer Prevention and Control Program, University of South Carolina, Columbia; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia; Center for Research in Nutrition and Health Disparities, University of South Carolina, Columbia.

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9M
Expanding Mentoring Capacity in High-Risk PopulationsK05CA136975 · NCI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI HEBERT, JAMES R · 2009 to 2013
$801k
Dietary Inflammatory Index and Risk of Cancer in WomenF31CA177255 · NCI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI TABUNG, FRED KINYUY · 2013 to 2013
$37k
Intramural NIH HHSNCI NIH HHS F31 CA177255NCI NIH HHS K05 CA136975NCI NIH HHS P30 CA060553NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNIA NIH HHS HHSN271201100004CWHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

purposeMany dietary factors have either proinflammatory or anti-inflammatory properties. We previously developed a dietary inflammatory index (DII) to assess the inflammatory potential of diet. In this study, we conducted a construct validation of the DII based on data from a food frequency questionnaire and three inflammatory biomarkers in a subsample of 2567 postmenopausal women in the Women's Health Initiative Observational Study.

methodsWe used multiple linear and logistic regression models, controlling for potential confounders, to test whether baseline DII predicted concentrations of interleukin-6, high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor alpha receptor 2, or an overall biomarker score combining all three inflammatory biomarkers.

resultsThe DII was associated with the four biomarkers with beta estimates (95% confidence interval) comparing the highest with lowest DII quintiles as follows: interleukin-6: 1.26 (1.15-1.38), Ptrend < .0001; tumor necrosis factor alpha receptor 2: 81.43 (19.15-143.71), Ptrend = .004; dichotomized hs-CRP (odds ratio for higher vs. lower hs-CRP): 1.30 (0.97-1.67), Ptrend = .34; and the combined inflammatory biomarker score: 0.26 (0.12-0.40), Ptrend = .0001.

conclusionsThe DII was significantly associated with inflammatory biomarkers. Construct validity of the DII indicates its utility for assessing the inflammatory potential of diet and for expanding its use to include associations with common chronic diseases in future studies.

Indexed as

DietPostmenopauseAgedBiomarkersC-Reactive ProteinFemaleHumansInflammationInterleukin-6Linear ModelsLogistic ModelsMiddle AgedReceptors, Tumor Necrosis Factor, Type IIBiomarkersC-Reactive ProteinIL6 protein, humanInterleukin-6Receptors, Tumor Necrosis Factor, Type IITNFRSF1B protein, humanConstruct validationDietary inflammatory indexInflammatory biomarkersWomen's Health Initiative

Identifiers

PMID25900255
PMCPMC4433562

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.