Evidence map›Paper›PMID 25900226›Full record

ReviewEpilepsy & behavior : E&B2015

Autism spectrum disorder and epilepsy: Disorders with a shared biology.

Bo Hoon Lee, Tristram Smith, Alex R Paciorkowski

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Epilepsy & behavior : E&B, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Review
  9. Article
  10. Article
  11. Article
  12. A missense mutation in theJournal of medicine and life · 2024
    Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Bo Hoon LeeDepartment of Pediatrics, University of Rochester Medical Center, Rochester, NY, USA.
Tristram SmithDivision of Neurodevelopmental and Behavioral Pediatrics, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, USA.
Alex R PaciorkowskiDepartment of Pediatrics, University of Rochester Medical Center, Rochester, NY, USA; Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA; Center for Neural Development and Disease, University of Rochester Medical Center, Rochester, NY, USA. Electronic address: Alex_Paciorkowski@urmc.rochester.edu.

Funding

Adaptive Interventions for Minimally Verbal Children with ASD in the CommunityR01HD073975 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KASARI, CONNIE L. · 2012 to 2016
$13.0M
2/3-Multisite RCT of Early Intervention for Spoken Communication in AutismR01MH084870 · NIMH · UNIVERSITY OF ROCHESTER · PI SMITH, TRISTRAM H · 2009 to 2013
$1.9M
Biology of developmental encephalopathies presenting with infantile spasmsK08NS078054 · NINDS · UNIVERSITY OF ROCHESTER · PI PACIORKOWSKI, ALEXANDER R · 2013 to 2017
$779k
NICHD NIH HHS R01 HD073975NIMH NIH HHS R01 MH084870NINDS NIH HHS K08 NS078054NINDS NIH HHS K08NS078054
6 · The paper itself

Abstract

There is an increasing recognition of clinical overlap in patients presenting with epilepsy and autism spectrum disorder (ASD), and a great deal of new information regarding the genetic causes of both disorders is available. Several biological pathways appear to be involved in both disease processes, including gene transcription regulation, cellular growth, synaptic channel function, and maintenance of synaptic structure. We review several genetic disorders where ASD and epilepsy frequently co-occur, and we discuss the screening tools available for practicing neurologists and epileptologists to help determine which patients should be referred for formal ASD diagnostic evaluation. Finally, we make recommendations regarding the workflow of genetic diagnostic testing available for children with both ASD and epilepsy. This article is part of a Special Issue entitled "Autism and Epilepsy".

Indexed as

Autism Spectrum DisorderChildEpilepsyGene Expression RegulationGenetic TestingHumansSynapsesAutismAutism spectrum disorderEpilepsyGenetic testing

Identifiers

PMID25900226
PMCPMC4475437

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.