ReviewCurrent rheumatology reports2015
Multicentric reticulohistiocytosis: a critical review.
Review in Current rheumatology reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Multicentric Reticulohistiocytosis Induced Alopecia: A Clinical Case Report.Journal of cutaneous pathology · 2026Article
- Successful treatment of multicentric reticulohistiocytosis with JAK inhibitor: a case series.RMD open · 2026Article
- Upadacitinib-Induced Remission in Multicentric Reticulohistiocytosis: Expanding the Therapeutic Role of JAK Inhibition.International journal of molecular sciences · 2026Article
- Unraveling cutaneous histiocytosis: insights into histology, pathogenesis, diagnosis, and treatment pitfalls.Frontiers in medicine · 2025Review
- Article
- Top Ten Lymphoproliferative Lesions Not to Miss When Evaluating Oral Ulcer Biopsies.Head and neck pathology · 2023Review
- Systemic lupus erythematosus with multicentric reticulohistiocytosis: A case report.World journal of clinical cases · 2023Article
- Multicentric Reticulohistiocytosis Associated with an Early Form of Systemic Lupus Erythematosus: A Case Report of a Rare Disease, with Mini Review of the Literature.Journal of clinical medicine · 2022Review
- Multicentric reticulohistiocytosis with prominent skin lesions and arthritis: A case report.World journal of clinical cases · 2022Article
- Clinical characteristics of multicentric reticulohistiocytosis and distinguished features from rheumatoid arthritis: a single-center experience in China.Orphanet journal of rare diseases · 2022Article
- Musculoskeletal imaging features of non-Langerhans cell histiocytoses.Skeletal radiology · 2021Review
- The combined prevalence of classified rare rheumatic diseases is almost double that of ankylosing spondylitis.Orphanet journal of rare diseases · 2021Article
- The Crucial Questions on Synovial Biopsy: When, Why, Who, What, Where, and How?Frontiers in medicine · 2021Review
- Case Report: Multicentric Reticulohistiocytosis Associated With Posterior Mediastinal Adenosquamous Carcinoma, Antinuclear Antibody Positivity and Lupus Anticoagulant Positivity.Frontiers in immunology · 2021Article
- Synovial Non-langerhans Cell Histiocytosis of the Shoulder: A Case Report and Review of the Literature.Journal of orthopaedic case reports · 2020Article
- Multicentric reticulohistiocytosis: A case report with response to adalimumab.Clinical case reports · 2020Article
- Multicentric reticulohistiocytosis in a patient with thymic carcinoma.JAAD case reports · 2019Article
- [Multicentric reticulohistiocytosis].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2018Article
- The utility of FDG-PET/CT imaging in the evaluation of multicentric reticulohistiocytosis: A case report.Medicine · 2018Article
- Looks Can Be Deceiving: A Case Report on Multicentric Reticulohistiocytosis Successfully Treated with Rituximab.Cureus · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The literature reports approximately 300 cases of multicentric reticulohistiocytosis (MRH) worldwide, mostly women of Caucasian origin. MRH manifests as a symmetric erosive polyarthritis mimicking rheumatoid arthritis with the subsequent appearance of typical papulonodular skin lesions. The disease may rapidly progress towards mutilans arthritis in the majority of cases, but it generally remits spontaneously in 10 years. The only diagnostic hallmark for MRH is the observation at histology of numerous histiocytes and multinucleated giant cells and ground glass eosinophilic cytoplasm. Despite its rarity, clinical and pathogenetic challenging features characterize the condition. First, the differential diagnosis with other forms of arthritis and the frequent coexistence of neoplasms or autoimmune diseases warrant a careful evaluation of suspected cases. Second, data from isolated MRH cases are consistent in supporting a role for monocyte/macrophage cells and for an enhanced osteoclastic activity in the affected tissues. Third, beside anti-inflammatory treatments, promising reports suggest that biologics targeting TNF-alpha and bisphosphonates may prove beneficial in MRH. Based on these observations, we are convinced that our understanding of this rare condition may prove beneficial in mechanistic advancement for other more prevalent inflammatory conditions such as arthritidies and other bone diseases.
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