Evidence map›Paper›PMID 25900168›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2015

Genital inflammation and the risk of HIV acquisition in women.

Lindi Masson, Jo-Ann S Passmore, Lenine J Liebenberg, Lise Werner, Cheryl Baxter, Kelly B Arnold, Carolyn Williamson, Francesca Little, Leila E Mansoor, Vivek Naranbhai and 11 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 286 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
286citing papers in PubMed, 5 pooled it
24.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

286 citing papers in PubMed, 5 syntheses or guidelines pooled it, 420 citations in OpenAlex.

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  14. Genital inflammatory status and the innate immune response to contraceptive initiation.American journal of reproductive immunology (New York, N.Y. : 1989) · 2022
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  16. Persistent, Asymptomatic Colonization withMicrobiology spectrum · 2022
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226 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 7 institutions in 3 countries.

Lindi MassonCentre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, University of Cape Town.
Jo-Ann S PassmoreCentre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, University of Cape Town National Health Laboratory Services, Cape Town, South Africa.
Lenine J LiebenbergCentre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban.
Lise WernerCentre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban.
Cheryl BaxterCentre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban.
Kelly B ArnoldDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge.
Carolyn WilliamsonCentre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, University of Cape Town.
Francesca LittleDepartment of Statistical Sciences, University of Cape Town.
Leila E MansoorCentre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban.
Vivek NaranbhaiCentre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban.
Douglas A LauffenburgerDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge.
Katharina RonacherNational Research Foundation of South Africa/Department of Science and Technology Centre of Excellence for TB Biomedical Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, South Africa.
Gerhard WalzlNational Research Foundation of South Africa/Department of Science and Technology Centre of Excellence for TB Biomedical Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, South Africa.
Nigel J GarrettCentre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban.
Brent L WilliamsCenter for Infection and Immunity.
Mara Couto-RodriguezCenter for Infection and Immunity.
Mady HornigCenter for Infection and Immunity.
W Ian LipkinCenter for Infection and Immunity.
Anneke GroblerCentre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban.
Quarraisha Abdool KarimCentre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York.
Salim S Abdool KarimCentre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York.
Centre for the AIDS Programme of Research in South Africa · ZAInstitute of Infection and Immunity · CAUniversity of KwaZulu-Natal · ZAMassachusetts Institute of Technology · USStellenbosch University · ZAColumbia University · USUniversity of Cape Town · ZA

Funding

The Viral Set Point in HIV-1 Subtype C InfectionU19AI051794 · NIAID · UNIVERSITY OF KWAZULU-NATAL · PI ABDOOL KARIM, SALIM S · 2002 to 2007
$22.5M
ROLE OF TRANSCRIPTION FACTOR CTCF IN TUMOR DEVELOPMENTZ01AI000859 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI LOBANENKOV, VICTOR · 2000 to 2003
–
Intramural NIH HHS Z01 AI000859NIAID NIH HHS AI51794NIAID NIH HHS U19 AI051794NIAID NIH HHS U19-AI0859Wellcome Trust
6 · The paper itself

Abstract

backgroundWomen in Africa, especially young women, have very high human immunodeficiency virus (HIV) incidence rates that cannot be fully explained by behavioral risks. We investigated whether genital inflammation influenced HIV acquisition in this group.

methodsTwelve selected cytokines, including 9 inflammatory cytokines and chemokines (interleukin [IL]-1α, IL-1β, IL-6, tumor necrosis factor-α, IL-8, interferon-γ inducible protein-10 [IP-10], monocyte chemoattractant protein-1, macrophage inflammatory protein [MIP]-1α, MIP-1β), hematopoietic IL-7, and granulocyte macrophage colony-stimulating factor, and regulatory IL-10 were measured prior to HIV infection in cervicovaginal lavages from 58 HIV seroconverters and 58 matched uninfected controls and in plasma from a subset of 107 of these women from the Centre for the AIDS Programme of Research in South Africa 004 tenofovir gel trial.

resultsHIV seroconversion was associated with raised genital inflammatory cytokines (including chemokines MIP-1α, MIP-1β, and IP-10). The risk of HIV acquisition was significantly higher in women with evidence of genital inflammation, defined by at least 5 of 9 inflammatory cytokines being raised (odds ratio, 3.2; 95% confidence interval, 1.3-7.9; P = .014). Genital cytokine concentrations were persistently raised (for about 1 year before infection), with no readily identifiable cause despite extensive investigation of several potential factors, including sexually transmitted infections and systemic cytokines.

conclusionsElevated genital concentrations of HIV target cell-recruiting chemokines and a genital inflammatory profile contributes to the high risk of HIV acquisition in these African women.

Indexed as

AfricaCervix UteriChemokine CCL2ChemokinesCytokinesDisease SusceptibilityFemaleGenital Diseases, FemaleGenitalia, FemaleHIV InfectionsHumansInflammationInterferon-gammaInterleukin-10Interleukin-6Interleukin-8CCL2 protein, humanChemokine CCL2ChemokinesCytokinesIL10 protein, humanInterferon-gammaInterleukin-10Interleukin-6Interleukin-8TNF protein, humanTumor Necrosis Factor-alphacytokinefemale genital tractHIV transmissioninflammation

Identifiers

PMID25900168
PMCPMC4565995
OpenAlexW2105053076

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.