ReviewCNS spectrums2015
Impulsivity and aggression in schizophrenia: a neural circuitry perspective with implications for treatment.
Review in CNS spectrums, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07434479 (A Virtual Reality Mindfulness Application for Aggression in Schizophrenia), which is not on this map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Virtual Reality Mindfulness Application for Aggression in Schizophrenia
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 136 citations in OpenAlex.
- An overlapping pattern of cerebral cortical thinning is associated with both positive symptoms and aggression in schizophrenia via the ENIGMA consortium.Psychological medicine · 2020Pooled it
- Computerized cognitive and social cognition training in schizophrenia for impulsive aggression.Schizophrenia research · 2023Trial
- Early improvements of individual symptoms as a predictor of treatment response to asenapine in patients with schizophrenia.Neuropsychopharmacology reports · 2020Trial
- Neuromodulators of orbitofrontal cortex function: A review of endocannabinoid, neurotrophin, and cell adhesion systems.Neurobiology of disease · 2026Review
- A ventral hippocampus to nucleus accumbens pathway regulates impulsivity in male but not female rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- The Role of Emotion Dysregulation, Impulsiveness and Rumination in Psychopathology: Evidence from an Italian Sample of Adolescents and Young Adults.Brain sciences · 2026Article
- Social cognitive deficits and their relationship with clinical symptoms in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2026Article
- Article
- A ventral hippocampus to nucleus accumbens pathway regulates impulsivity.bioRxiv : the preprint server for biology · 2025Article
- The Left-Hand 2D:4D Ratio is Superior to the Right-Hand 2D:4D Ratio in Determining the Criminal Potential of Schizophrenia Patients.Alpha psychiatry · 2025Article
- Neural correlates of aggression in schizophrenia: An event-related potential study using the competitive reaction time task.World journal of psychiatry · 2025Article
- Genomic structural equation modeling of impulsivity and risk-taking traits reveals three latent factors distinctly associated with brain structure and development.bioRxiv : the preprint server for biology · 2025Article
- Mediating effect of risk propensity between impulsivity and psychotic experiences among Lebanese young adults.Discover mental health · 2025Article
- Chronotype and sleep quality in forensic psychiatric patients with schizophrenia: exploring their interplay with aggressive and impulsive traits.Dusunen adam : Bakirkoy Ruh ve Sinir Hastaliklari Hastanesi yayin organi · 2025Article
- The study on agitation and structure of orbitofrontal cortex subregion in first-episode drug-naïve patients with schizophrenia.Brain imaging and behavior · 2025Article
- Metabolic pathway modulation by olanzapine: Multitarget approach for treating violent aggression in patients with schizophrenia.World journal of psychiatry · 2025Article
- Article
- Behavioral characterization of triple-hit schizophrenia-like Lisket rats derived from the Long Evans strain through acute and chronic behavioral tests.Frontiers in psychiatry · 2025Article
- Aberrant glutamatergic systems underlying impulsive behaviors: Insights from clinical and preclinical research.Progress in neuro-psychopharmacology & biological psychiatry · 2024Review
- On the effects of impulsivity and compulsivity on neural correlates of model-based performance.Scientific reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Elevations of impulsive behavior have been observed in a number of serious mental illnesses. These phenomena can lead to harmful behaviors, including violence, and thus represent a serious public health concern. Such violence is often a reason for psychiatric hospitalization, and it often leads to prolonged hospital stays, suffering by patients and their victims, and increased stigmatization. Despite the attention paid to violence, little is understood about its neural basis in schizophrenia. On a psychological level, aggression in schizophrenia has been primarily attributed to psychotic symptoms, desires for instrumental gain, or impulsive responses to perceived personal slights. Often, multiple attributions can coexist during a single aggressive incident. In this review, I discuss the neural circuitry associated with impulsivity and aggression in schizophrenia, with an emphasis on implications for treatment. Impulsivity appears to account for a great deal of aggression in schizophrenia, especially in inpatient settings. Urgency, defined as impulsivity in the context of strong emotion, is the primary focus of this article. It is elevated in several psychiatric disorders, and in schizophrenia, it has been related to aggression. Many studies have implicated dysfunctional frontotemporal circuitry in impulsivity and aggression in schizophrenia, and pharmacological treatments may act via that circuitry to reduce urgency and aggressive behaviors; however, more mechanistic studies are critically needed. Recent studies point toward manipulable neurobehavioral targets and suggest that cognitive, pharmacological, neuromodulatory, and neurofeedback treatment approaches can be developed to ameliorate urgency and aggression in schizophrenia. It is hoped that these approaches will improve treatment efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.