Evidence map›Paper›PMID 25899656›Full record

ReviewCurrent cardiology reports2015

A Comparison of Vasodilating and Non-vasodilating Beta-Blockers and Their Effects on Cardiometabolic Risk.

Icilma V Fergus, Kenneth L Connell, Keith C Ferdinand

Abstract readComparative StudyReview
PubMed Publisher
In one paragraph

Review in Current cardiology reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Beta-blockers for hypertension.The Cochrane database of systematic reviews · 2017
    Pooled it
  2. Therapeutics in Metabolic Diseases.Advances in experimental medicine and biology · 2023
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Icilma V FergusMount Sinai School of Medicine, One Gustave L. Levy Place, Box 1030, New York, NY, 10029, USA, icilma.fergus@mountsinai.org.
Kenneth L Connell
Keith C Ferdinand
Icahn School of Medicine at Mount Sinai · USTulane University · USUniversity of the West Indies System · JM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiometabolic risk describes a collection of risk factors, with a likely underlying pathophysiology, resulting in accelerated atherosclerosis and the terminal cardiovascular events of myocardial infarction and stroke. Beta-blockers, which are divided as vasodilators or non-vasodilators, are used in the treatment of hypertension and other cardiovascular diseases. Vasodilators have been shown to be of particular benefit in both blood pressure control and other cardiometabolic components with limited disturbance in metabolic parameters. Nebivolol, a third-generation beta-blocker (BB), acts by increasing nitric oxide (NO) bioavailability. This property may be especially important in NO-deficient population, such as black people, in regulating both blood pressure control and glucose homeostasis.

Indexed as

Adrenergic beta-AntagonistsBlood PressureCardiovascular DiseasesClinical Trials as TopicEthnicityHumansInsulin ResistanceNebivololNitric OxideObesityPractice Guidelines as TopicRisk FactorsVasodilator AgentsAdrenergic beta-AntagonistsNebivololNitric OxideVasodilator Agents

Identifiers

PMID25899656
OpenAlexW2090494044

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.