ArticleEuropean radiology2015
Quantification of tumour (18) F-FDG uptake: Normalise to blood glucose or scale to liver uptake?
Article in European radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Effect of blood glucose level on standardized uptake value (SUV) inEuropean journal of nuclear medicine and molecular imaging · 2019Pooled it
- Effects of blood glucose level on 18F-FDG uptake for PET/CT in normal organs: A systematic review.PloS one · 2018Pooled it
- Development and Testing of a Machine Learning Model UsingKorean journal of radiology · 2023Trial
- Estimation of liver standardized uptake value in F18-FDG PET/CT scanning: impact of different malignancies, blood glucose level, body weight normalization, and imaging systems.Annals of nuclear medicine · 2025Article
- Exploratory Dual PET imaging of [Bioorganic & medicinal chemistry letters · 2024Article
- It's Not What You Take Up, It's What You Keep: How Discoveries from Diverse Disciplines Directed the Development of the FDG PET/CT Scan.Digestive diseases and sciences · 2022Article
- Can Dynamic Whole-Body FDG PET Imaging Differentiate between Malignant and Inflammatory Lesions?Life (Basel, Switzerland) · 2022Article
- Intrapatient variability of 18F-FDG uptake in normal tissues.Journal of clinical imaging science · 2022Article
- FDG-PET/CT imaging findings of hepatic tumors and tumor-like lesions based on molecular background.Japanese journal of radiology · 2020Review
- A 3D deep convolutional neural network approach for the automated measurement of cerebellum tracer uptake in FDG PET-CT scans.Medical physics · 2020Article
- Assessing and reducing PET radiotracer infiltration rates: a single center experience in injection quality monitoring methods and quality improvement.BMC medical imaging · 2020Article
- Diagnostic accuracy of 18F-FDG-PET in abdominal sepsis in rats.Acta cirurgica brasileira · 2020Article
- The PET-Derived Tumor-to-Liver Standard Uptake Ratio (SUVFrontiers in oncology · 2020Article
- Effect of various blood glucose levels on regional FDG uptake in the brain.Asia Oceania journal of nuclear medicine & biology · 2020Article
- Article
- Effects of plasma glucose levels on regional cerebral 18F-fluorodeoxyglucose uptake: Implications for dementia evaluation with brain PET imaging.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2019Article
- Diabetes Mellitus-Related Fractional Glucose Uptake in Men and Women Imaged WithJournal of the Endocrine Society · 2019Article
- The appropriate whole body metric for calculating standardised uptake value and the influence of sex.Nuclear medicine communications · 2019Article
- Effects of blood glucose level on 18F fluorodeoxyglucose (18F-FDG) uptake for PET/CT in normal organs: an analysis on 5623 patients.Scientific reports · 2018Article
- The extent to which standardized uptake values reflect FDG phosphorylation in the liver and spleen as functions of time after injection ofEJNMMI research · 2017Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare normalisation to blood glucose (BG) with scaling to hepatic uptake for quantification of tumour (18) F-FDG uptake using the brain as a surrogate for tumours.
methodsStandardised uptake value (SUV) was measured over the liver, cerebellum, basal ganglia, and frontal cortex in 304 patients undergoing (18) F-FDG PET/CT. The relationship between brain FDG clearance and SUV was theoretically defined.
resultsBrain SUV decreased exponentially with BG, with similar constants between cerebellum, basal ganglia, and frontal cortex (0.099-0.119 mmol/l(-1)) and similar to values for tumours estimated from the literature. Liver SUV, however, correlated positively with BG. Brain-to-liver SUV ratio therefore showed an inverse correlation with BG, well-fitted with a hyperbolic function (R = 0.83), as theoretically predicted. Brain SUV normalised to BG (nSUV) displayed a nonlinear correlation with BG (R = 0.55); however, as theoretically predicted, brain nSUV/liver SUV showed almost no correlation with BG. Correction of brain SUV using BG raised to an exponential power of 0.099 mmol/l(-1) also eliminated the correlation between brain SUV and BG.
conclusionBrain SUV continues to correlate with BG after normalisation to BG. Likewise, liver SUV is unsuitable as a reference for tumour FDG uptake. Brain SUV divided by liver SUV, however, shows minimal dependence on BG. KEY POINTS: • FDG standard uptake value in tumours helps clinicians assess response to treatment. • SUV is influenced by blood glucose; normalisation to blood glucose is recommended. • An alternative approach is to scale tumour SUV to liver SUV. • The brain used as a tumour surrogate shows that neither approach is valid. • Applying both approaches, however, appropriately corrects for blood glucose.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.