ArticlePlant cell reports2015
Functional analysis of β-amyrin synthase gene in ginsenoside biosynthesis by RNA interference.
Article in Plant cell reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 39 citations in OpenAlex.
- Single-cell analyses identify the ginseng embryonic protoderm as a native compartment for high-efficiency ginsenoside production.Nature communications · 2026Article
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- Methyl Jasmonate- and Salicylic Acid-Induced Transcription FactorInternational journal of molecular sciences · 2023Article
- Genes and Regulatory Mechanisms for Ginsenoside Biosynthesis.Journal of plant biology = Singmul Hakhoe chi · 2023Review
- Integrated metabolome and transcriptome analysis identifies candidate genes involved in triterpenoid saponin biosynthesis in leaves ofFrontiers in plant science · 2023Article
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- Overexpression of BcERF3 increases the biosynthesis of saikosaponins in Bupleurum chinense.FEBS open bio · 2022Article
- TheFrontiers in plant science · 2022Review
- Synthetic biology of plant natural products: From pathway elucidation to engineered biosynthesis in plant cells.Plant communications · 2021Review
- Transcriptome analysis identifies putative genes involved in triterpenoid biosynthesis in Platycodon grandiflorus.Planta · 2021Article
- Ginsenosides inActa pharmaceutica Sinica. B · 2021Review
- ARPI, β-AS, and UGE regulate glycyrrhizin biosynthesis in Glycyrrhiza uralensis hairy roots.Plant cell reports · 2021Article
- Insights into triterpene synthesis and unsaturated fatty-acid accumulation provided by chromosomal-level genome analysis of Akebia trifoliata subsp. australis.Horticulture research · 2021Article
- Functional characterization of a WRKY family gene involved in somatic embryogenesis in Panax ginseng.Protoplasma · 2020Article
- MicroRNA-mediated regulation of ginsenoside biosynthesis inScience progressReview
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key messageDown-regulation of β-amyrin synthase gene expression by RNA interference led to reduced levels of β-amyrin and oleanane-type ginsenoside as well as up-regulation of dammarane-type ginsenoside level. In the biosynthetic pathway of ginsenosides, β-amyrin synthase catalyzes the reaction from oxidosqualene to β-amyrin, the proposed aglycone of oleanane-type saponins. Here, RNAi was employed to evaluate the role of this gene in ginsenoside biosynthesis of Panax ginseng hairy roots. The results showed that RNAi-mediated down-regulation of this gene led to reduced levels of β-amyrin and oleanane-type ginsenoside Ro as well as increased level of total ginsenosides, indicating an important role of this gene in biosynthesis of ginsenoside. Expression of key genes involved in dammarane-type ginsenoside including genes of dammarenediol synthase and protopanaxadiol and protopanaxatriol synthases were up-regulated in RNAi lines. While expression of squalene synthase genes was not significantly changed, β-amyrin oxidase gene was down-regulated. This work will be helpful for further understanding ginsenoside biosynthesis pathway.
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