Evidence map›Paper›PMID 25899067›Full record

ArticleThe international journal of neuropsychopharmacology2015

Changed Synaptic Plasticity in Neural Circuits of Depressive-Like and Escitalopram-Treated Rats.

Xiao-Li Li, Yong-Gui Yuan, Hua Xu, Di Wu, Wei-Gang Gong, Lei-Yu Geng, Fang-Fang Wu, Hao Tang, Lin Xu, Zhi-Jun Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 71 citations in OpenAlex.

  1. Article
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  5. Article
  6. Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  7. Article
  8. Article
  9. Role ofAnnals of neurosciences · 2023
    Article
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  18. Article
  19. Frontiers in nutrition · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Xiao-Li LiDepartment of Neurology, Affiliated ZhongDa Hospital, Neuropsychiatric Institute and Medical School of Southeast University, Nanjing, Jiangsu, China (Drs Li, Yuan, H. Xu, D. Wu, Gong, Geng, F-F. Wu, Tang, and Zhang); Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China (Dr L. Xu); Graduate School of Chinese Academy of Sciences, Beijing, China (Dr L. Xu)X-L.L. and Y-G.Y. contributed equally to this work.
Yong-Gui YuanDepartment of Neurology, Affiliated ZhongDa Hospital, Neuropsychiatric Institute and Medical School of Southeast University, Nanjing, Jiangsu, China (Drs Li, Yuan, H. Xu, D. Wu, Gong, Geng, F-F. Wu, Tang, and Zhang); Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China (Dr L. Xu); Graduate School of Chinese Academy of Sciences, Beijing, China (Dr L. Xu)X-L.L. and Y-G.Y. contributed equally to this work.
Hua XuDepartment of Neurology, Affiliated ZhongDa Hospital, Neuropsychiatric Institute and Medical School of Southeast University, Nanjing, Jiangsu, China (Drs Li, Yuan, H. Xu, D. Wu, Gong, Geng, F-F. Wu, Tang, and Zhang); Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China (Dr L. Xu); Graduate School of Chinese Academy of Sciences, Beijing, China (Dr L. Xu)X-L.L. and Y-G.Y. contributed equally to this work.
Di WuDepartment of Neurology, Affiliated ZhongDa Hospital, Neuropsychiatric Institute and Medical School of Southeast University, Nanjing, Jiangsu, China (Drs Li, Yuan, H. Xu, D. Wu, Gong, Geng, F-F. Wu, Tang, and Zhang); Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China (Dr L. Xu); Graduate School of Chinese Academy of Sciences, Beijing, China (Dr L. Xu)X-L.L. and Y-G.Y. contributed equally to this work.
Wei-Gang GongDepartment of Neurology, Affiliated ZhongDa Hospital, Neuropsychiatric Institute and Medical School of Southeast University, Nanjing, Jiangsu, China (Drs Li, Yuan, H. Xu, D. Wu, Gong, Geng, F-F. Wu, Tang, and Zhang); Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China (Dr L. Xu); Graduate School of Chinese Academy of Sciences, Beijing, China (Dr L. Xu)X-L.L. and Y-G.Y. contributed equally to this work.
Lei-Yu GengDepartment of Neurology, Affiliated ZhongDa Hospital, Neuropsychiatric Institute and Medical School of Southeast University, Nanjing, Jiangsu, China (Drs Li, Yuan, H. Xu, D. Wu, Gong, Geng, F-F. Wu, Tang, and Zhang); Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China (Dr L. Xu); Graduate School of Chinese Academy of Sciences, Beijing, China (Dr L. Xu)X-L.L. and Y-G.Y. contributed equally to this work.
Fang-Fang WuDepartment of Neurology, Affiliated ZhongDa Hospital, Neuropsychiatric Institute and Medical School of Southeast University, Nanjing, Jiangsu, China (Drs Li, Yuan, H. Xu, D. Wu, Gong, Geng, F-F. Wu, Tang, and Zhang); Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China (Dr L. Xu); Graduate School of Chinese Academy of Sciences, Beijing, China (Dr L. Xu)X-L.L. and Y-G.Y. contributed equally to this work.
Hao TangDepartment of Neurology, Affiliated ZhongDa Hospital, Neuropsychiatric Institute and Medical School of Southeast University, Nanjing, Jiangsu, China (Drs Li, Yuan, H. Xu, D. Wu, Gong, Geng, F-F. Wu, Tang, and Zhang); Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China (Dr L. Xu); Graduate School of Chinese Academy of Sciences, Beijing, China (Dr L. Xu)X-L.L. and Y-G.Y. contributed equally to this work.
Lin XuDepartment of Neurology, Affiliated ZhongDa Hospital, Neuropsychiatric Institute and Medical School of Southeast University, Nanjing, Jiangsu, China (Drs Li, Yuan, H. Xu, D. Wu, Gong, Geng, F-F. Wu, Tang, and Zhang); Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China (Dr L. Xu); Graduate School of Chinese Academy of Sciences, Beijing, China (Dr L. Xu)X-L.L. and Y-G.Y. contributed equally to this work.
Zhi-Jun ZhangDepartment of Neurology, Affiliated ZhongDa Hospital, Neuropsychiatric Institute and Medical School of Southeast University, Nanjing, Jiangsu, China (Drs Li, Yuan, H. Xu, D. Wu, Gong, Geng, F-F. Wu, Tang, and Zhang); Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China (Dr L. Xu); Graduate School of Chinese Academy of Sciences, Beijing, China (Dr L. Xu)X-L.L. and Y-G.Y. contributed equally to this work. janemengzhang@vip.163.com.
Chinese Academy of Sciences · CNKunming Institute of Zoology · CNSoutheast University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough progress has been made in the detection and characterization of neural plasticity in depression, it has not been fully understood in individual synaptic changes in the neural circuits under chronic stress and antidepressant treatment.

methodsUsing electron microscopy and Western-blot analyses, the present study quantitatively examined the changes in the Gray's Type I synaptic ultrastructures and the expression of synapse-associated proteins in the key brain regions of rats' depressive-related neural circuit after chronic unpredicted mild stress and/or escitalopram administration. Meanwhile, their depressive behaviors were also determined by several tests.

resultsThe Type I synapses underwent considerable remodeling after chronic unpredicted mild stress, which resulted in the changed width of the synaptic cleft, length of the active zone, postsynaptic density thickness, and/or synaptic curvature in the subregions of medial prefrontal cortex and hippocampus, as well as the basolateral amygdaloid nucleus of the amygdala, accompanied by changed expression of several synapse-associated proteins. Chronic escitalopram administration significantly changed the above alternations in the chronic unpredicted mild stress rats but had little effect on normal controls. Also, there was a positive correlation between the locomotor activity and the maximal synaptic postsynaptic density thickness in the stratum radiatum of the Cornu Ammonis 1 region and a negative correlation between the sucrose preference and the length of the active zone in the basolateral amygdaloid nucleus region in chronic unpredicted mild stress rats.

conclusionThese findings strongly indicate that chronic stress and escitalopram can alter synaptic plasticity in the neural circuits, and the remodeled synaptic ultrastructure was correlated with the rats' depressive behaviors, suggesting a therapeutic target for further exploration.

Indexed as

AnimalsAntidepressive AgentsBlotting, WesternBody WeightBrainChronic DiseaseCitalopramDepressive DisorderDietary SucroseDisease Models, AnimalFeeding BehaviorMaleMicroscopy, ElectronMotor ActivityNeural PathwaysNeuronal PlasticityAntidepressive AgentsCitalopramDietary SucrosedepressionplasticityratSynapse

Identifiers

PMID25899067
PMCPMC4648155
OpenAlexW2147047225

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