SynthesisBMC medicine2015
A systematic review of cost-effectiveness analyses of complex wound interventions reveals optimal treatments for specific wound types.
Synthesis in BMC medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 66 citations in OpenAlex.
- Topically administered purified clinoptilolite-tuff for the treatment of cutaneous wounds: A prospective, randomised phase I clinical trial.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2022Trial
- Comment on "Meta-Analysis of Cost-Effectiveness" by Bang and Zhao: Combinability, Joint Modeling, and a Two-Stage Framework for Cost-Effectiveness Analysis Synthesis.Statistics in medicine · 2026Article
- A Systematic Review of the Cost-Effectiveness of Interventions for Chronic Wounds.International wound journal · 2026Review
- Meta-Analysis of Cost-Effectiveness.Statistics in medicine · 2026Article
- Low-value clinical practices in pressure injury management: a scoping review.BMC health services research · 2025Article
- Cannabinoids in Integumentary Wound Care: A Systematic Review of Emerging Preclinical and Clinical Evidence.Pharmaceutics · 2024Review
- Challenges around quantifying uncertainty in a holistic approach to hard-to-heal wound management: Health economic perspective.International wound journal · 2023Article
- Potential predictors of quality of life in patients with venous leg ulcers: A cross-sectional study in Taiwan.International wound journal · 2022Article
- Application of Alginate-Based Hydrogels in Hemostasis.Gels (Basel, Switzerland) · 2022Review
- Accelerated burn wound healing with photobiomodulation therapy involves activation of endogenous latent TGF-β1.Scientific reports · 2021Article
- Knockdown of Dual Oxidase 1 (DUOX1) Promotes Wound Healing by Regulating Reactive Oxygen Species (ROS) by Activation of Nuclear Kactor kappa B (NF-κB) Signaling.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Development of Bacterial Cellulose Biocomposites Combined with Starch and Collagen and Evaluation of Their Properties.Materials (Basel, Switzerland) · 2021Article
- Cost-effectiveness analysis of domiciliary topical sevoflurane for painful leg ulcers.PloS one · 2021Article
- Biofilm-Innate Immune Interface: Contribution to Chronic Wound Formation.Frontiers in immunology · 2021Review
- An economic evaluation examining the cost-effectiveness of continuous diffusion of oxygen therapy for individuals with diabetic foot ulcers.International wound journal · 2020Article
- Bayesian Regression Model for a Cost-Utility and Cost-Effectiveness Analysis Comparing Punch Grafting Versus Usual Care for the Treatment of Chronic Wounds.International journal of environmental research and public health · 2020Observational
- Article
- Can supernatant from immortalized adipose tissue MSC replace cell therapy? An in vitro study in chronic wounds model.Stem cell research & therapy · 2020Article
- [Research progress in adipose tissue promoted wound healing].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2019Review
- An improvement in acute wound healing in mice by the combined application of photobiomodulation and curcumin-loaded iron particles.Lasers in medical science · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundComplex wounds present a substantial economic burden on healthcare systems, costing billions of dollars annually in North America alone. The prevalence of complex wounds is a significant patient and societal healthcare concern and cost-effective wound care management remains unclear. This article summarizes the cost-effectiveness of interventions for complex wound care through a systematic review of the evidence base.
methodsWe searched multiple databases (MEDLINE, EMBASE, Cochrane Library) for cost-effectiveness studies that examined adults treated for complex wounds. Two reviewers independently screened the literature, abstracted data from full-text articles, and assessed methodological quality using the Drummond 10-item methodological quality tool. Incremental cost-effectiveness ratios were reported, or, if not reported, calculated and converted to United States Dollars for the year 2013.
resultsOverall, 59 cost-effectiveness analyses were included; 71% (42 out of 59) of the included studies scored 8 or more points on the Drummond 10-item checklist tool. Based on these, 22 interventions were found to be more effective and less costly (i.e., dominant) compared to the study comparators: 9 for diabetic ulcers, 8 for venous ulcers, 3 for pressure ulcers, 1 for mixed venous and venous/arterial ulcers, and 1 for mixed complex wound types.
conclusionsOur results can be used by decision-makers in maximizing the deployment of clinically effective and resource efficient wound care interventions. Our analysis also highlights specific treatments that are not cost-effective, thereby indicating areas of resource savings. Please see related article: http://dx.doi.org/10.1186/s12916-015-0288-5.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.