Evidence map›Paper›PMID 25899040›Full record

ArticleLipids2015

Maternal high-fat-diet programs rat offspring liver fatty acid metabolism.

Emily L Seet, Jennifer K Yee, Juanita K Jellyman, Guang Han, Michael G Ross, Mina Desai

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lipids, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
9.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
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  9. Maternal High-Fat Diet and Offspring Hypertension.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Emily L SeetDepartment of Obstetrics and Gynecology, Perinatal Research Laboratories, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 West Carson Street Box 446, RB-1 Bldg., Torrance, CA, 90502, USA.
Jennifer K Yee
Juanita K Jellyman
Guang Han
Michael G Ross
Mina Desai
UCLA Medical Center · USHarbor–UCLA Medical Center · USThe Lundquist Institute · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Mechanisms of Programmed Gestational HyperphagiaR01HD054751 · NICHD · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ROSS, MICHAEL GLENN · 2008 to 2012
$1.4M
Programmed Adipogenesis and Lipid DysregulationR01DK081756 · NIDDK · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI DESAI, MINA · 2010 to 2014
$1.4M
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NICHD NIH HHS R01 HD054751NICHD NIH HHS R01HD054751NIDDK NIH HHS R01 DK081756NIDDK NIH HHS R01DK081756
6 · The paper itself

Abstract

In offspring exposed in utero to a maternal diet high in fat (HF), we have previously demonstrated that despite similar birth weights, HF adult offspring at 6 months of age had significantly higher body weights, greater adiposity, and increased triacylglycerol (TAG) levels as compared to controls. We hypothesized that a maternal HF diet predisposes to offspring adiposity via a programmed increase in the synthesis of monounsaturated fatty acids in the liver and hence increased substrate availability for liver TAG synthesis. We further hypothesized that programmed changes in offspring liver fatty acid metabolism are associated with increased liver expression of the lipogenic enzyme stearoyl-CoA desaturase-1 (SCD-1). Female rats were maintained on a HF diet rich in monounsaturated fatty acids (MUFA) prior to and throughout pregnancy and lactation. After birth, newborns were nursed by the same dam, and all offspring were weaned to control diet. Plasma and liver fatty acid compositions were determined using gas chromatography/mass spectrometry. Fatty acid C16 desaturation indices of palmitoleic/palmitic and (vaccenic + palmitoleic)/palmitic and the C18 desaturation index of oleic/stearic were calculated. Liver protein abundance of SCD-1 was analyzed in newborns and adult offspring. Plasma and liver C16 desaturation indices were decreased in HF newborns, but increased in the adult offspring. Liver SCD-1 expression was increased in the HF adult offspring. These data show that the maternal HF diet during pregnancy and lactation increases offspring liver SCD-1 protein abundance and alters the liver C16 desaturase pathway.

Indexed as

Diet, High-FatMaternal Nutritional Physiological PhenomenaAnimalsDisease Models, AnimalFatty Acids, MonounsaturatedFemaleLiverMaleMetabolic Networks and PathwaysObesityRats, Sprague-DawleyStearoyl-CoA DesaturaseTriglyceridesFatty Acids, MonounsaturatedStearoyl-CoA Desaturasestearoyl-CoA desaturase SCD-1, ratTriglycerides

Identifiers

PMID25899040
PMCPMC4451084
OpenAlexW2075746012

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.