ArticleIn vitro cellular & developmental biology. Animal2015
Validation of an in vitro model of erbB2(+) cancer cell redirection.
Article in In vitro cellular & developmental biology. Animal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Intercellular mitochondrial transfer contributes to microenvironmental redirection of cancer cell fate.The FEBS journal · 2025Article
- Tumor-treating fields and concurrent cisplatin: anAmerican journal of cancer research · 2025Article
- Optimization of tumor-treating field therapy for triple-negative breast cancer cells in vitro via frequency modulation.Cancer cell international · 2023Article
- Review
- Induction of phenotypic changes in HER2-postive breast cancer cellsOncotarget · 2020Article
- Redirecting Normal and Cancer Stem Cells to a Mammary Epithelial Cell Fate.Journal of mammary gland biology and neoplasia · 2019Review
- Amphiregulin regulates proliferation and migration of HER2-positive breast cancer cells.Cellular oncology (Dordrecht, Netherlands) · 2018Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Overexpression of the oncoprotein erbB2/HER2 is present in 20-30% of breast cancer patients and inversely correlates with patient survival. Reports have demonstrated the deterministic power of the mammary microenvironment where the normal mammary microenvironment redirects cells of non-mammary origin or tumor-derived cells to adopt a mammary phenotype in an in vivo model. This phenomenon is termed tumor cell redirection. Tumor-derived cells that overexpress the erbB2 oncoprotein lose their tumor-forming capacity in this model. In this model, phosphorylation of erbB2 is attenuated thus reducing the tumor cell's tumor-forming potential. In this report, we describe our results using an in vitro model based on the in vivo model mentioned previously. Tumor-derived cells are mixed in predetermined ratios with normal mammary epithelial cells prior to seeding in vitro. In this in vitro model, the tumor-derived cells are redirected as determined by attenuated phosphorylation of the receptor and reduced sphere and colony formation. These results match those observed in the in vivo model. This in vitro model will allow expanded experimental options in the future to determine additional aspects of tumor cell redirection that can be translated to other types of cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.